Industrial process monitoring is a critical application of multivariate time-series (MTS) anomaly detection, especially crucial for safety-critical systems such as nuclear power plants (NPPs). However, some current data-driven process monitoring approaches may not fully capitalize on the temporal-spatial correlations inherent in operational MTS data. Particularly, asynchronous time-lagged correlations may exist among variables in actual NPPs, which further complicates this challenge. In this work, a reconstruction-based MTS anomaly detection approach based on a temporal-spatial transformer is proposed. It employs a two-stage temporal-spatial attention mechanism combined with a multi-scale strategy to learn the dependencies within normal operational data at various scales, thereby facilitating the extraction of temporal-spatial correlations from asynchronous MTS. Experiments on simulated datasets and real NPP datasets demonstrate that the proposed model possesses stronger feature learning capabilities, as evidenced by its improved performance in signal reconstruction and anomaly detection for asynchronous MTS data. Moreover, the proposed TS-Trans model enables earlier detection of anomalous events, which holds significant importance for enhancing operational safety and reducing potential losses in NPPs.