Currently, the governments of many countries are facing with a lack of funds for financing programs for social protection of population. Among the causes of this problem, we can indicate the high unemployment rate, which, among other things, is due to implementation of labor-saving technologies. The purpose of this work is to study the impact of technological changes on the sustainability of the state social security system in Ukraine. The general approaches to the assessment of the stability of the state social security system are described. The simulation of the effect of economically efficient technological changes on the company’s income and expenses was carried out. Some patterns of such changes are established. The group of productive technological changes types is presented. The model is developed, and an indicator of the impact estimation of efficiently effective technological changes on the stability of the state social security system is proposed. The analysis of the main indicators of the state social security system functioning of Ukraine is carried out. The dynamics of indicators characterizing the labor market of Ukraine is analyzed. The influence of changes in labor productivity on costs and profits by industries of Ukraine is estimated. The evaluation of the impact of economically efficient technological changes in the industries of Ukraine on the stability of its state social security system is carried out. The different state authorities can use the obtained results for developing measures to manage the sustainability of the state social security system.