Intrapreneurial Self-Capital (ISC) represents a promising individual resource that might be enhanced through intervention to help individuals cope adaptively with the ongoing changes that characterize the world of work and other life challenges in the 21st century. In order to examine the promise of this construct, the present study analyzed the relationship between ISC and both hedonic and eudaimonic well-being, controlling for the effects of personality traits, which are substantially stable and not amenable to psychological intervention. The Intrapreneurial Self-Capital Scale (ISCS), the Big Five Questionnaire (BFQ), the Positive and Negative Affect Schedule (PANAS), the Satisfaction With Life Scale (SWLS), the Meaning in Life Measure (MLM), and the Flourishing Scale (FS), were administered to 563 Italian university students. Hierarchical regressions analyses showed that ISC explained a percentage of incremental variance beyond that accounted for by personality traits in relation to both hedonic and eudaimonic well-being. These results support the premise that ISC may be a promising resource for fostering both hedonic and eudaimonic well-being.