Sustainability is a global issue and its enhancement through modern forms of procurements, such as public-private partnership (PPP), has become topical considering the huge impact of PPP activities on society, the economy, and the environment. However, one way of promoting sustainability thorough PPPs is the adoption of social responsibility (SR) initiatives/factors. This paper aims to empirically investigate the SR factors in PPPs through a comparative study between China and Ghana. An empirical questionnaire survey was conducted in both China and Ghana. Further, the mean score ranking, Kendall’s coefficient of concordance, and Mann-Whitney U test were used for data analysis. Results show that SR factors related to the economic efficiency of PPP projects and climate change adaptation are critical in China, whereas in Ghana, SR factors directly related to job creation and environmental protection are critical. The outputs of this study inform investors of the critical SR initiatives to consider when engaging in PPPs in Asia and Africa. In addition, they provide a solid knowledge base for the continuous international debate on how sustainability could be enhanced through PPP policy.