Use of photovoltaic modules in buildings has been reported to be an effective tool in managing energy consumption. The novelty in the research herein is in a framework that integrates different performance parameters through the use of an experimental design to expect all variables via linear regression analysis. An emphasis is placed on making the method readily available to practitioners and experts in the area of renewable energy, using standard procedure and easily accessible software. This work empowers the decision-making process and sustainability through a parametric analysis of the installation of photovoltaic modules to increase their energy output towards nearly zero energy buildings. A case study of a group of photovoltaic modules is examined in four cities with different locations and climate data to validate the proposed framework. Results demonstrate that the installation of photovoltaic modules on the mounted roof is better than elevations, and the vertical installation of modules is the worst possible inclination to maximize the yielded energy. The impact of inclination is higher than orientation in influencing the energy productivity of photovoltaic modules. This work specifies integrating such modules mounted on roofs and elevations towards the equator line, by a proportion of inclination/latitude equal to 85 ± 3%, to maximize the energy output.