As one of the most important design tasks of building design, space layout design affects the building energy performance (BEP). In order to investigate the effect, a literature review of relevant papers was performed. Ten relevant articles were found and reviewed in detail. First, a methodology for studying the effects of space layouts on BEP were proposed regarding design variables, energy indicators and BEP calculation methods, and the methodologies used in the 10 articles were reviewed. Then, the effects of space layouts on energy use and occupant comfort were analysed separately. The results show that the energy use for heating, cooling, lighting and ventilation is highly affected by space layouts, as well as thermal and visual comfort. The effects of space layouts on energy use are higher than on occupant comfort. By changing space layouts, the resulting reductions in the annual final energy for heating and cooling demands were up to 14% and 57%, respectively, in an office building in Sweden. The resulting reductions in the lighting demand of peak summer and winter were up to 67% and 43%, respectively, for the case of an office building in the UK, and the resulting reduction in the air volume supplied by natural ventilation was 65%. The influence of other design parameters, i.e., occupancy and window to wall ratio, on the effects of space layouts on BEP was also identified.