This research sets out to examine the interaction between accessibility, social inequalities and sustainability by revisiting a well-documented case of inequalities in access in Global South cities: Bogotá. Our analysis builds on the concept of accessibility, focusing on the role of transport as an enabler of opportunities for social interactions, healthcare and leisure, which are essential to the full participation in society. The research applies a methodological framework for accessibility developed and tested in the Latin American context, though it has not been previously applied to non-commuting travel. Our paper contributes to the existing evidence base showing the relevance of non-commuting travel to sustainable transport assessment in contexts of high inequality, which can be scaled up and applied in other contexts with various levels of social and environmental inequalities. The empirical analysis is based on data from Bogotá’s household travel survey. Using this dataset, we measure accessibility using a gravitational type of metric that is calibrated based on observed travel behavior. Accessibility levels were estimated by car and public transport for every zonal planning unit in the Bogotá Region. Accessibility indices are analyzed from an equity perspective using metrics such as the Palma ratio for differences of income and socioeconomic positions. Results show that on average, low- and middle-income areas have higher accessibility than high-income areas by both private and public transport. Accessibility conditions are discussed considering a framework of transitions to sustainable urban mobility, reflecting on various drivers and consequences of barriers to access in different areas and social groups. Our findings provide insights to support actions that redistribute accessibility of opportunities beyond the job market, questioning the applicability of accessibility measures to discuss equity and sustainability in cities such as Bogotá.