This study investigates how the structural mix of USA regional economies affects their volatility of economic growth. Four exogenous sectors are chosen for this investigation: Federal Government, construction, manufacturing, and tourism. Perhaps unsurprisingly, evidence suggests that a larger share of Federal Government employment in an economy reduces the variability of overall employment growth, while a larger share of construction activity elevates it. More telling is a finding that, recently, manufacturing has not contributed as much to such variability, and that a larger tourism presence increases it. The increasing integration of technology in tourism offers significant opportunities for a network approach and innovation in regional development.