One of the biggest challenges of our time is climate change. Every day, at different places of the world, the planet sends alarming messages about the enormous transformations it is experiencing due to human-based activities. The latter are responsible for changing weather patterns that threaten food production, energy production and energy consumption, the desertification of land, the displacement of people and animals because of food and water shortages due to the reductions in rainfall, natural disasters and rising sea levels. The effects of climate change affect us all, and if drastic measures are not considered in a timely manner, it will be more difficult and costly to adapt to the aforementioned effects in the future. Considering this context, the aim of this work is to implement a prospective study/structural analysis to the identified sectors of a regional plan of adaptation to climate change so as to promote the resilience of the region against the negative phenomena generated by the climate crisis. This was achieved in two steps: first, we identified the relationships between the strategic sectors of the plan and organized them in order of importance. Second, we assessed the effectiveness of several public policies oriented towards a city’s resilience according to their impact upon the strategic sectors of the plan and the co-benefits generated by their implementation for society. The results highlight that the most essential sectors for the mitigation of climate change are flood risk management, built environment, forest ecosystem management, human health, tourism and rise in sea level. As a consequence, the most important measures for the resilience of the North Aegean Region against climate change are the ones related to the preparation of strategic master plans for flood protection projects.