Tunnel–bridge–tunnel groups (TBTGs) are emerging roads that often involve simple road alignments, but complex driving environments. Investigating crashes occurred in TBTGs is essential for revealing the driving environment–adaptability relationships for such roads. This study seeks to analyze the crash characteristics of component sections in TBTGs with different driving environments and compare the impact of differences in the key factor on the crashes. After TBTGs were defined through a proposed safety-critical distance metric determined via visual theory and actual crash analyses, an eight-zone analytical method considering road types and lighting was developed to probe into crashes in TBTGs. The results show that the proper safety-critical distances for bridge–tunnel and tunnel–tunnel groups are 150 and 500 m, respectively. In TBTGs, the crash rate in ordinary sections is higher than that in bridges and tunnels, particularly in the access zone. The first passed tunnel witnesses a higher proportion of crashes at the access zone and transition zone than the second tunnel. The influence of bridge and tunnel ratios on crashes is related to the ratio and type of bridges and tunnels. The findings presented herein can provide evidence-based guidance for the safety design and management of TBTGs.