To prevent the transmission of the Coronavirus (SARS-CoV-2) in the public, the demand and consumption of personal protective equipment (PPE) increased drastically. Such wide use of PPE has brough a new challenge to waste management and disposal. It is difficult to sort PPE waste before further treatment, and such waste will often end up being processed by some traditional disposal methods. During the pandemic, incineration and landfill facilities are currently under significant pressure. In addition, a certain amount of PPE waste is discarded into the environment rather than going to landfills and incinerators. It not only directly affects the ecosystem, but also indirectly threatens human health through various routes of exposure. PPE waste is also the source and carrier of pathogens and chemical contaminants, causing a secondary pollution. Therefore, it is necessary to establish appropriate strategies to deal with the PPE problems related to energy, environment and health, requiring the collaborative efforts of researchers, practitioners, policymakers, and governments.