Industrial heritage with secular production activity constitutes a specific field of application to refine digital tools for knowledge within the HBIM (Heritage Building Information Modeling) process. Industrial sites are traditionally linked to the exploitation of local resources, and, not infrequently, are settled by recovering the ruins of ancient buildings and monuments. The Sanctuary of Hercules in Tivoli represents a significant case study that moves between classical and industrial archaeology, in particular the “Cartierà Segrè”, hereinafter referred to as former Segrè papermill, to test ArchaeoBIM concepts and to investigate current and lost heritage. Starting from the documents and the digital survey with the use of UAV videogrammetry, the aim is the construction of the informative model with particular attention to the 4D management to describe the evolution phases and the exploration of the construction specificities of buildings and machines between pre-modern techniques and industrial age. The results show the possibility of creating a diachronic HBIM to investigate a complex industrial heritage, its evolution and production phases, modeling components for this type of architecture, with the deepening of the LOD of BIM (Building Information Modeling) instances applied to machines. The application represents an augmented knowledge process applicable on industrial heritage through modeling instances of machines and industrial processes that would allow regional and transnational cross-sectional studies and the enhancement of fruition and reuse of these sites.