The large size of a glazed component allows greater access to natural light inside and a wider view of the outdoors while protecting the inside from extreme weather conditions. However, glazed components make buildings energy inefficient compared to opaque components if not designed suitably, and sometimes they create glare discomforts too. In order to protect against excessive natural light and direct sunlight and for privacy, dynamic shading devices are integrated into the glazed façade. In this study, the impact of various glazing and shading design parameters has been investigated by performing uncertainty and sensitivity analyses. The uncertainty analysis indicates that the variance coefficients for the source energy use, lighting energy use, useful daylight illuminance (UDI), and shade-deployed time fraction are in the ranges of 15.04–30.47, 39.05–45.06, 40.57–49.92, and 19.35–52%, respectively. The dispersion in the energy and indoor visual performance is evident by the large variation in the source energy consumption and UDI (500–2000), which vary in the ranges of 250–450 kWh/(m2-year) and 5–90%. Furthermore, a sensitivity analysis identified the window-to-wall ratio (WWR), aspect ratio (ASR), glazing type (Gt), absorptance of the wall (Aw), and shade transmittance (ST) as major influences of the parameters. Each of the identified parameters has a different proportionate impact depending on the façade orientation and performance parameters.