There is an increasing call for science to contribute more to real-world solutions for a sustainability transformation. At the same time, the scientific landscape encompasses different concepts, which are characterized as practice-oriented, addressing social challenges and wicked problems, which thus offer potential to contribute to a transformation, notably: technology assessment (TA), responsible research and innovation (RRI), and real-world labs (RwLs). This article deals with the question of how these different concepts can be better integrated to contribute to a transformation. With this goal in mind, we analyze the three concepts, show their core characteristics, and identify their common key similarities. TA and RRI have rarely been connected to transformative sustainability research in general or RwLs in particular. Based on the key similarities and respective strengths of the three concepts, we suggest four ways to integrate the approaches, including the novel endeavor of a Reflexive Sustainable Technology Lab as the highest level of the concepts’ synthesis.