The rock mass deformation modulus (Em) is an essential input parameter in numerical modeling for assessing the rock mass behavior required for the sustainable design of engineering structures. The in situ methods for determining this parameter are costly and time consuming. Their results may not be reliable due to the presence of various natures of joints and following difficult field testing procedures. Therefore, it is imperative to predict the rock mass deformation modulus using alternate methods. In this research, four different predictive models were developed, i.e., one statistical model (Muti Linear Regression (MLR)) and three Artificial Intelligence models (Artificial Neural Network (ANN), Random Forest Regression (RFR), and K-Neighbor Network (KNN)) by employing Rock Mass Rating (RMR89) and Point load index (I50) as appropriate input variables selected through correlation matrix analysis among eight different variables to propose an appropriate model for the prediction of Em. The efficacy of each predictive model was evaluated by using four different performance indicators: performance coefficient R2, Mean Absolute Error (MAE), Mean Squared Error (MSE), and Median Absolute Error (MEAE). The results show that the R2, MAE, MSE, and MEAE for the ANN model are 0.999, 0.2343, 0.2873, and 0.0814, respectively, which are better than MLR, KNN, and RFR. Therefore, the ANN model is proposed as the most appropriate model for the prediction of Em. The findings of this research will provide a better understanding and foundation for the professionals working in fields during the prediction of various engineering parameters, especially Em for sustainable engineering design in the rock engineering field.