The rapid development of tourism has put forward new requirements for the training of tourism talents. This study conducted a cross-regional questionnaire survey on tourism management undergraduate students from 28 tourism colleges in seven regions of China. PLS method was used to explore the relevant influencing factors of students’ learning gain. The study concluded that: (1) Students’ gain in professional knowledge reserve, learning ability, innovation ability, teamwork ability and social ethics have a significantly positive impact on students’ employment situation. (2) Internship and employment guidance plays an important role in the influence of college investment on students’ learning gain. (3) Student engagement plays an important mediating role in the relationship between teaching factors (such as learning curriculum and teachers’ teaching quality) and students’ learning gain. (4) The college’s learning guidance and advice collection can effectively improve students’ learning gain, but the impact of the college’s environmental facilities on the sense of acquisition of tourism management students is not significant. This paper provides important implications for the improvement of talent mechanism of tourism education.