This research introduces a sustainable, metaverse-based vocational preparation program designed to empower adults with disabilities, providing them with the necessary skills to secure and retain employment in a landscape drastically altered by the Fourth Industrial Revolution and the COVID-19 pandemic. After implementing the program with nine adults with disabilities, the Wilcoxon signed-rank test was used to analyze the differences in the pre- and post-tests of the study participants. As a result, the participants’ interpersonal relationships, problem-solving abilities in the workplace, and online interview skills were significantly improved. This study holds significance in its innovative approach to vocational education, adapting to shifts in employment trends and providing interventions in the metaverse that transcend traditional educational settings.