The COVID-19 pandemic disrupted global supply chains, posing significant challenges to the textile and clothing industry. However, amidst these threats, there is a unique opportunity to rebuild a more sustainable and resilient fashion industry. This paper explores the shift from pre-COVID-19 business models and consumption values towards a renaissance characterized by real sustainability. By examining the transition from eco-efficiency to eco-effectiveness and from cradle-to-grave to cradle-to-cradle approaches, this study emphasizes the need for the active involvement of key stakeholders in co-creating value for all. Through a comprehensive analysis of the post-COVID era, this study aims to understand textile and clothing industry professionals’ perceptions and attitudes towards sustainable design practices and identify challenges in implementing such strategies. The findings contribute to the knowledge of sustainability in the post-COVID era and provide insights and strategies for textile and clothing industry players to thrive in a sustainable and transformed landscape.