The European Union is working on strategies in order to increase the energy efficiency of buildings. A useful solution is to identify the energy performance of buildings through the Energy Performance Certificate (EPC), as it provides information for the comparison of buildings with different architectural typology, shape, design technology and geographic location. However, this tool does not assess the real energy consumption of the building and does not always take into account its impact on the environment. In this work, two different types of analysis were carried out: one based only on the energy efficiency and the other one based on the environmental impact. Those analyses were applied on a standard building, set in three different Italian locations, with the purpose of obtaining cross-related information. After the evaluation of the results, interventions on some parameters (walls insulation, windows frame, filler gas in the insulated glazing) have been identified in order to improve the energy behavior of the building with an acceptable environmental impact. The aim of this paper is to propose a methodology that integrates the EPC with green building rating systems, leading to a more conscious choice of retrofit interventions as a compromise between energy performances and environmental impact.