Wastewater treatment plants (WWTPs) exhibit significant energy consumption and produce large amounts of Greenhouse Gas emissions (GHG emissions). Energy efficiency and reduction in GHG emissions in WWTPs have become important issues, especially in view of the climate crisis. The core objective of this work is to assess the energy and carbon footprint of Greek WWTPs and to propose methods to improve energy efficiency and reduce GHG emissions. Data were collected from 31 Greek WWTPs with an average treatment capacity between 250 and 3,650,000 population equivalents (PE). The total population served by the 31 WWTPs was over 6,000,000, which is more than half of the population in Greece with access to WWTPs. Based on the results, the annual average energy consumption for small, medium and large WWTPs equals 137 kWh/PE, 48 kWh/PE and 32 kWh/PE, respectively. Accordingly, annual average GHG emissions, both biogenic and non-biogenic in small, medium and large WWTPs are equal to 207 kgCO2e/PE, 144 kgCO2e/PE and 89 kgCO2e/PE, respectively. Annual average on-site GHG emissions are equal to 56.5 kgCO2e/PE, while the average off-site GHG emissions account for 16.9 kgCO2e/PE. Based on the results, acceptable and attainable targets for WWTPs energy consumption and GHG emissions are proposed.