Hydrogen fuel cell vehicles are expected to play an important role in the future and thus have improved significantly over the past years. Hydrogen fuel cell motorcycles with a small container for compressed hydrogen gas have been developed in Japan along with related regulations. As a result, national regulations have been established in Japan after discussions with Japanese motorcycle companies, stakeholders, and experts. The concept of Japanese regulations was proposed internationally, and a new international regulation on hydrogen-fueled motorcycles incorporating compressed hydrogen storage systems based on this concept are also established as United Nations Regulation No. 146. In this paper, several technical regulations on hydrogen safety specific to fuel cell motorcycles incorporating compressed hydrogen storage systems are summarized. The unique characteristics of these motorcycles, e.g., small body, light weight, and tendency to overturn easily, are considered in these regulations.