Abstract. The design of foundations for offshore wind turbines (OWTs) requires the assessment of long-term performance of the soil–structure interaction (SSI), which is subjected to many cyclic loadings. In terms of serviceability limit state (SLS), it has to be ensured that the load on the foundation does not exceed the operational tolerance prescribed by the wind turbine manufacturer throughout its lifetime. This work aims at developing a probabilistic approach along with a reliability framework with emphasis on verifying the SLS criterion in terms of maximum allowable rotation during an extreme cyclic loading event. This reliability framework allows the quantification of uncertainties in soil properties and the constitutive soil model for cyclic loadings and extreme environmental conditions and verifies that the foundation design meets a specific target reliability level. A 3D finite-element (FE) model is used to predict the long-term response of the SSI, accounting for the accumulation of permanent cyclic strain experienced by the soil. The proposed framework was employed for the design of a large-diameter monopile supporting a 10 MW offshore wind turbine.