Abstract. Offshore wind turbine (OWT) support structures are exposed to the risk of fatigue damage and scour, and this risk can be effectively mitigated by installing structural control devices such as tuned mass dampers (TMDs). However, time-varying scour altering OWTs' dynamic characteristics has an impact on the TMD design and fatigue life, which has rarely been studied before. In this paper, a simplified modal model is used to investigate the influence of scour and a TMD on the fatigue life evaluation of a 5 MW OWT's support structure, and a traditional method and a newly developed optimization technique are both presented to obtain TMD parameters. This optimization technique aims at finding optimal parameters of the TMD which maximize the fatigue life of a hotspot at the mudline, and the effect of time-varying scour can be considered. This study assumes that the TMD operates in the fore–aft (FA) direction, while the vibration in the side–side (SS) direction is uncontrolled. Results show that scour can decrease the fatigue life by about 24.1 % and that the TMD can effectively suppress vibration and increase the fatigue life. When the scour depth reaches 1.3 times the pile diameter, the TMD with a mass ratio of 1 % can increase the fatigue life of an OWT's support structure by about 64.6 %. Further, it is found that the fatigue life can be extended by 25 % with the TMD optimized by the proposed optimization technique rather than using a traditional design method which does not take the change in dynamic characteristics into account.