Aim of study: A two-year experiment (2021-2022) was conducted to assess the response of a local maize hybrid BL-43 to different water regimes (full irrigation, deficit irrigation and rainfed) at two distinguished pedo-climatic locations (Aleksandrovac and Butmir) in Bosnia and Herzegovina (BiH). Area of study: The field experiment was located in Aleksandrovac (near Banja Luka) and Butmir (near Sarajevo) in BiH. Material and methods: A randomized block design was adopted at both experimental locations with three replicates. An Excel-based irrigation tool was used to manage crop water requirements and irrigation scheduling. Main results: Crop response to water was affected by site-specific agronomic management, the duration of phenological stages and their interconnection with precipitation events. At both locations, the effect of the water inputs on grain yield was statistically significant confirming the beneficial impact of irrigation. The effect of water stress on yield was particularly pronounced at Aleksandrovac, which was under water and temperature stresses during flowering time. During both seasons and for all water regimes, the total average grain yield was greater at Butmir than at Aleksandrovac for 38% and 27%, respectively. Research highlights: This is the first experimental study conducted in BiH on the effect of irrigation on maize grain production under different pedoclimatic conditions. The study emphasizes the need for knowledge regarding the impacts that climate change is having on the productivity of one of the region's most important crops.