The contribution, based on the real case study of the Friuli-Venezia Giulia region, proposes a critical reflection on the model of Ecologically Equipped Production Areas (APEA), highlighting the importance of a broader vision that can integrate the different scales of intervention with the specificities of the contexts to which they belong, intertwining economic, social and spatial dynamics. From this point of view, Italy, as a center of the Mediterranean basin, can represent a context of experimentation for the reuse and regeneration of production areas, also increasing the competitiveness of the national production system.