Renewed COVID-19 outbreaks and uneven vaccination progress are prolonging the fight against the disease in developing Asia. This is contributing to a divergence in growth paths in the region that is partly being determined by the progress on tackling COVID-19. Asian Development Outlook 2021 Update raises regional growth forecasts for East Asia and Central Asia, and revises them down for South Asia, Southeast Asia, and the Pacific. The main risks to the region’s economic prospects still center on the pandemic, particularly the emergence of new variants, lagging vaccine rollouts, and waning vaccine effectiveness. As economies recover from the pandemic, the threats of climate change will take center stage again. Sustainable food production and agricultural systems that are resilient to climate change will be crucial for developing Asia. To transform agriculture in the region, its economies must tackle challenges from changing consumer demand, changing demographics, and a changing and more fragile environment.