The propensity for sustainability represents one of the most difficult challenges globally in recent decades. The programs of 2030 Agenda define some objectives related to construction including the increase in housing, the promotion of social inclusion and the upgrading of healthcare structures. The main objective of the research is the definition of an instrument to support the administrations to identify buildings suitable for transformation in social housing and healthcare constructions, with reference to public asset with a cultural value, disused or "badly used". Through multi-criteria evaluations based on the analysis of parametric indicators, the methodology intends to define a protocol useful for the purposes already mentioned and for meta-project guidelines that guarantee a sustainable approach to the transformation and regeneration of the real estate in question. The initial objectives and methodological aspects are presented in this paper.