A large part of the Italian territory is characterized by a spatial organization structured in small towns, with natural and cultural resources, vast material and immaterial heritage, and economic potential. All features often mirrored by a limited accessibility to essential services (transportation, health, and education systems), depopulation and high building vulnerability and inefficiency. The aim of this paper is to propose a methodology for the systemic definition of intervention strategies for building recovery and valorization, as part of a more complex strategy of inner areas’ revitalization, to be achieved in accordance with the cultural landscape, local construction techniques and materials, and the specific characteristics of considered buildings. The chosen case study has been the small town of Conza della Campania, whose historic center was almost destroyed by the 1980’s Irpinia earthquake; although abandoned since, the damaged building stock still preserves acknowledged architectural and constructive qualities, and the area has many potentials linked to its natural and productive vocations. Applying the methodology, seismic and energy retrofitting strategies resulted in the definition of adaptive abacuses describing the most efficient interventions for each considered building, derived by detailed analysis related to their construction techniques, architectural features, historical evolution, and artistic/cultural values. In terms of urban regeneration, these abacuses, as basis for seismic and energy building recovery, act as adaptive tools to support the definition of compatible operational choices and ensure the development of sustainable strategies leading to holistic results.