Systemic view in Strategic Environmental Management is gaining even more attention. The paper proposes the case of a Territorial Environmental and Social Assessment (TESA), based on a Life-cycle approach, applied to set-up the Matera Provincial Plan for a strategic environmental management. Information for performing LCA is here integrated through an Energy-Social Planning model as a decisional support tool. The city-owned buildings are critical facilities for Territorial energy management: the focus here is mainly on energy efficiency. The results obtained of the study contribute to reach EU targets according to the new Directive of the European Parliament and of the Council on the energy performance of buildings.