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Experimental Cell Research

Article . 1998

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[The effect of Beta-mercaptoethanol on the incorporation of precursors of proteins and nucleic acids into mouse liver and intestine].

Name: [The effect of Beta-mercaptoethanol on the incorporation of precursors of proteins and nucleic acids into mouse liver and intestine].
Keywords: Intestines, Ethanol, Liver, Leucine, Nucleic Acids, Proteins, Proteins -- metabolism, Nucleosides, DNA, Sulfhydryl Compounds

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1998 Belgium French Journal:Experimental cell research, volume 27 (issn: 0014-4827,

Authors: Brachet, Jean; MIRAUX-JONCKHEERE, A;

pmid: 14014786

handle: 2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/173181

[The effect of Beta-mercaptoethanol on the incorporation of precursors of proteins and nucleic acids into mouse liver and intestine].

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Abstract

1. 1. We have studied the effects of an intraperitoneal injection of β-mercaptoethanol (2 mg/20 g body weight) on nucleic acid and protein synthesis in the liver and intestine of mice. The incorporation of 3H-thymidine, 3H-cytidine and 3H-leucine has been followed by autoradiography. 2. 2. The experiments have shown that β-mercaptoethanol inhibits mitotic activity and incorporation of thymidine into DNA in the intestine. 3. 3. The incorporation of cytidine and that of leucine are also strongly inhibited in the intestine as well as in the liver. The inhibition is of the same order of magnitude for the nucleus and the cytoplasm (except for cytidine, in the case of intestinal nuclei). In the liver, the incorporation of both precursors is higher in the nucleus than in the cytoplasm, while the opposite situation holds for the intestine. 4. 4. The significance of these results is briefly discussed. © 1962. ; Journal Article ; SCOPUS: ar.j ; info:eu-repo/semantics/published

Country

Belgium

Related Organizations

Université Libre de Bruxelles
Belgium

Keywords

Intestines, Ethanol, Liver, Leucine, Nucleic Acids, Proteins, Proteins -- metabolism, Nucleosides, DNA, Sulfhydryl Compounds, Sciences bio-médicales et agricoles, Mercaptoethanol, Thymidine

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%

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