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Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats

Name: Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats
Keywords: rats, stomach ulceration, ethanol, potassium channel modulators

descriptionPublicationkeyboard_double_arrow_right Article 31 Dec 2002 Canada English Publisher:University of Toronto

Authors: Majid Rahgozar; Hamid Reza Pazoki Toroudi; Azam Bakhtiarian; Bijan Djahanguiri;

handle: 1807/8894

Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats

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Abstract

Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated.

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Canada

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University of Toronto
Canada

Keywords

rats, stomach ulceration, ethanol, potassium channel modulators

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