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Bulletin of Experime...arrow_drop_down

Bulletin of Experimental Biology and Medicine

Article . 1982

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[Major histocompatibility system of the mouse (H-2) and body reaction to ethanol].

Name: [Major histocompatibility system of the mouse (H-2) and body reaction to ethanol].
Keywords: Male, Time Factors, Dose-Response Relationship, Drug, Ethanol, Congenic Resistant Lines:, Drug Tolerance, Motor Activity, Alcohol:, Mice, Mutant Strains, Major Histocompatibility Complex

descriptionPublicationkeyboard_double_arrow_right Article 21 Dec 1982 United States Russian Publisher:The Mouseion at the JAXlibraryJournal:Biulleten' eksperimental'noi biologii i meditsiny, volume 94 (issn: 0365-9615,

Authors: Shoshina, S V; Maiskii, A I;

pmid: 7126828

[Major histocompatibility system of the mouse (H-2) and body reaction to ethanol].

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Abstract

A study was made of the response to ethanol of 2 pairs of the congenic resistant (CR) mouse strains, B10.R107, B10.RIII and A/Sn, A.SW. Upon a single intraperitoneal injection of ethanol in a dose of 4 g/kg bw CR strains manifested pronounced ethanol narcosis, while doses of 1 and 2.5 g/kg produced marked locomotor reaction. As regards these tests B10.RIII and A.SW mice were more susceptible to alcohol while B10.R107 mice were more resistant. The changes in locomotor activity induced by ethanol were dose-dependent in all the strains under study. It was disclosed in the course of chronic alcoholization that B10.RIII and A.SW mice consume less amounts of 10% ethanol. Mouse susceptibility to a single ethanol injection recorded from the duration of alcoholic narcosis and locomotion was found to correlate negatively with the ethanol consumption rate. The participation of the H-2 system in the response to ethanol is discussed.

Country

United States

Related Organizations

Jackson Laboratory
United States
Jackson Laboratory
United States

Keywords

Male, Time Factors, Dose-Response Relationship, Drug, Ethanol, Congenic Resistant Lines:, Drug Tolerance, Motor Activity, Alcohol:, Mice, Mutant Strains, Major Histocompatibility Complex, Mice, Behavior:, Strains:, Animals, Pathology:, Hereditary Factors:, Serology:

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