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The relationship between impaired control, impulsivity, and alcohol self-administration in nondependent drinkers.

The relationship between impaired control, impulsivity, and alcohol self-administration in nondependent drinkers.
Impaired control over drinking is a significant marker of alcohol use disorder (AUD), and a potential target of intervention (Heather, Tebbutt, Mattick, & Zamir, 1993; Leeman, Toll, Taylor, & Volpicelli, 2009). Impaired control may be related to, but conceptually distinct from, impulsivity (Leeman, Patock-Peckham, & Potenza, 2012; Leeman, Ralevski, et al., 2014). However, the relationship between impaired control, impulsivity, and alcohol consumption, particularly in nondependent drinkers is less clear. This study aimed to characterize these relationships using a free-access intravenous alcohol self-administration (IV-ASA) paradigm in nondependent drinkers (N = 48). Results showed individuals with higher self-reported impaired control achieved higher blood alcohol concentrations (BAC) during the IV-ASA session and reported greater hedonic subjective responses to alcohol. Higher impaired control was also associated with greater positive urgency and reward sensitivity. Moderated-mediation analysis showed that the relationship between positive urgency and peak BAC was mediated by impaired control, and partially moderated by subjective alcohol response. These findings highlight the critical role of impaired control over drinking on alcohol consumption and subjective responses in nondependent drinkers. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
- National Institute On Alcohol Abuse and Alcoholism United States
- Centre for Addiction and Mental Health Canada
- National Institutes of Health United States
- Centre for Addiction and Mental Health Canada
- National Institute of Health Pakistan
Adult, Male, Alcohol Drinking, Ethanol, Self Administration, Middle Aged, Alcoholism, Young Adult, Reward, Impulsive Behavior, Humans, Administration, Intravenous, Female, Self Report
Adult, Male, Alcohol Drinking, Ethanol, Self Administration, Middle Aged, Alcoholism, Young Adult, Reward, Impulsive Behavior, Humans, Administration, Intravenous, Female, Self Report
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citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).29 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
