ProtoDUNE-SP at the CERN Neutrino Platform is a test bed liquid argon time pro- jection chamber (LArTPC) for the far-detector in the Deep Underground Neutrino Ex- periment (DUNE). Space charge eects, attenuation due to electronegative impurities, diusion, and electronics gain variations cause nonuniformities in charge deposition per unit length (dQ/dx) within a LArTPC. Corrections for space charge eects with measured electric-eld maps and attenuation with purity-monitor data were applied. A sample of cosmic-ray muons crossing the cathode is used to calibrate the detector response to get a uniform dQ/dx over space and time. Using cosmic-ray stopping muons, which have a well-known energy loss per unit length (dE/dx), the absolute energy scale was determined. These calibration factors were uploaded to a database for use in further physics analysis.