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Control of the specific growth rate of Bacillus subtilis for the production of biosurfactant lipopeptides in bioreactors with foam overflow

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Nov 2010 France Publisher:Elsevier BVJournal:Process Biochemistry, volume 45, pages 1,800-1,807 (issn: 1359-5113,

Authors: Chenikher, Salah; Guez, Jean Sébastien; Coutte, François; Pekpe, Komi Midzodzi; Jacques, Philippe; Cassar, Jean Philippe;

doi: 10.1016/j.procbio.2010.06.001

Control of the specific growth rate of Bacillus subtilis for the production of biosurfactant lipopeptides in bioreactors with foam overflow

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Abstract

This paper formulates a feeding law for a bioprocess dedicated to the production of an antibiotic surfactant using Bacillus subtilis. The specificity of the process relies on the use of the surface active property of the product to extract it by foaming. The control law is designed to maintain a constant specific biomass growth rate while taking into account the particularity of the process. This law can be regarded as a generalization of the conventional exponential feeding strategy and is generic enough to encompass the case of continuous processes with partial recycling. Conventional exponential feeding strategies indeed fail to account for the loss of biomass induced by the foaming. Previous experiments have provided a model of the process and values for its parameters. From this information, a feeding rate law was computed using the feeding strategy proposed in this paper and applied to an experimental culture. This experiment allows discussion of the modeling of the biomass extraction method used in this study. The results on the estimated specific growth rate highlight the complete agreement between the expected and experimental features. Further process optimization studies can now be performed on the basis of the constant specific biomass growth rate.

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France

Related Organizations

University of Lille 1
Université de Lille 2
France
University of Lille
France
Artois University
France
A K Industries (United Kingdom)
United Kingdom

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Keywords

[SDV.BIO]Life Sciences [q-bio]/Biotechnology, INFO_BT] Computer Science/Biotechnology [[INFO], [SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SDV]Life Sciences [q-bio], 610, Extraction, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SPI.AUTO]Engineering Sciences [physics]/Automatic, INFO_BT] Informatique/Biotechnologie [[INFO], [ SPI.AUTO ] Engineering Sciences [physics]/Automatic, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Fed-batch culture, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], AUTO] Engineering Sciences/Automatic [[SPI], 660, [SDV.BIO] Life Sciences/Biotechnology, Modeling, [ SDV.BIO ] Life Sciences [q-bio]/Biotechnology, BIO] Sciences du Vivant/Biotechnologies [[SDV], Biosurfactant production, Open-loop control, BIO] Life Sciences/Biotechnology [[SDV], AUTO] Sciences de l'ingénieur/Automatique / Robotique [[SPI], [SDV.BIO] Life Sciences [q-bio]/Biotechnology, [SDV] Life Sciences [q-bio], [SPI.AUTO] Engineering Sciences/Automatic, [SPI.AUTO] Engineering Sciences [physics]/Automatic, [INFO.INFO-BT] Computer Science [cs]/Biotechnology, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-BT] Computer Science/Biotechnology, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [ INFO.INFO-BT ] Computer Science [cs]/Biotechnology, Biotechnology

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