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Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 15 Dec 2023Publisher:Springer Science and Business Media LLCJournal:Nature Communications, volume 14 (eissn: 2041-1723, Copyright policy )Funded by:CIHR | unidentified
Authors: Michael A. Skinnider; Mopelola O. Akinlaja; Leonard J. Foster;

doi: 10.1038/s41467-023-44139-5

pmid: 38102123

pmc: PMC10724252

Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry

Abstract

AbstractWe present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.

Related Organizations
Keywords

Proteomics, Science, Q, Protein Interaction Mapping, Animals, Humans, Bees, Phosphorylation, Article, Mass Spectrometry

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 9
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Top 10%
Average
Top 10%
Green
gold