Concentrating photovoltaic has a major challenge due to the high temperature raised during the process which reduces the efficiency of the solar cell. A multi-layered microchannel heat sink technique is considered more efficient in terms of heat removal and pumping power among many other cooling techniques. Thus, in the current work, multi-layered microchannel heat sink is used for concentrating photovoltaic cooling. The thermal behavior of the system is experimentally and numerically investigated. The results show that in extreme heating load of 30 W/cm2 with heat transfer fluid flow rate of 30 mL/min, increasing the number of layers from one to four reduces the heat source temperature from 88.55 to 73.57 °C. In addition, the single layered MLM heat sink suffers from the highest non-uniformity in the heat source temperature compared to the heat sinks with the higher number of layers. Additionally, the results show that increasing the number of layers from one to four reduces the pressure drop from 162.79 to 32.75 Pa.