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Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure.

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Feb 2008 English Publisher:Govi-VerlagJournal:Die Pharmazie, volume 63 (issn: 0031-7144, Copyright policy )
Authors: Amir Ata Saei; Abolghasem Jouyban; Mohammad Amin Abolghassemi Fakhree; William E. Acree; Taravat Ghafourian;

doi: 10.1691/ph.2008.7670

pmid: 18380397

Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model--effect of solute structure.

Abstract

Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction capability of the model being approximately 13%.

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Keywords

Models, Statistical, Ethanol, Chemistry, Pharmaceutical, Water, Polyethylene Glycols, Models, Chemical, Pharmaceutical Preparations, Solubility, Data Interpretation, Statistical, Solvents, Computer Simulation, Algorithms, Software

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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