• Energy Research
• 2021-2025close
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In recent years, the continuous spread of the COVID-19 epidemic has impacted the supply chain of enterprises. Mitigating the supply chain’s vulnerability has great significance for the survival and development of enterprises. Optimizing the business environment and building a digital government will help improve the external environment for enterprise development. However, its impact on the vulnerability of the enterprise supply chain has yet to be studied. Taking the impact of COVID-19 as an example, this paper uses the survey data of nearly 40,000 enterprises of the National Federation of Industry and Commerce in 2020 and “10,000 private enterprises evaluating the business environment”, to conduct systematic empirical research and fill the research gap in this area. The study indicates that the business environment and digital government can significantly mitigate the impact of COVID-19 on the supply chain. This conclusion is still valid after a series of robustness tests. Mechanism analysis demonstrates that the business environment and digital government can prompt the government to introduce effective mitigation measures promptly, better guarantee production factors and logistics, and thus improve the vulnerability of the enterprise supply chain. This study deepens our understanding of the economic outcome of the business environment and digital government and also sheds new light on supply chain management.

The continual spread of novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posing a severe threat to the health worldwide. The main protease (Mpro, alias 3CLpro) of SARS-CoV-2 is a crucial enzyme for the maturation of viral particles and is a very attractive target for designing drugs to treat COVID-19. Here, we propose a multiple conformation-based virtual screening strategy to discover inhibitors that can target SARS-CoV-2 Mpro. Based on this strategy, nine Mpro structures and a protein mimetics library with 8960 commercially available compounds were prepared to carry out ensemble docking for the first time. Five of the nine structures are apo forms presented in different conformations, whereas the other four structures are holo forms complexed with different ligands. The surface plasmon resonance assay revealed that 6 out of 49 compounds had the ability to bind to SARS-CoV-2 Mpro. The fluorescence resonance energy transfer experiment showed that the biochemical half-maximal inhibitory concentration (IC50) values of the six compounds could hamper Mpro activities ranged from 0.69 ± 0.05 to 2.05 ± 0.92 μM. Evaluation of antiviral activity using the cell-based assay indicated that two compounds (Z1244904919 and Z1759961356) could strongly inhibit the cytopathic effect and reduce replication of the living virus in Vero E6 cells with the half-maximal effective concentrations (EC50) of 4.98 ± 1.83 and 8.52 ± 0.92 μM, respectively. The mechanism of the action for the two inhibitors were further elucidated at the molecular level by molecular dynamics simulation and subsequent binding free energy analysis. As a result, the discovered noncovalent reversible inhibitors with novel scaffolds are promising antiviral drug candidates, which may be used to develop the treatment of COVID-19.

Abstract The assessment of the time and frequency connectedness between cryptocurrencies and renewable energy stock markets is of key interest for portfolio diversification. In this paper, we utilize weekly data from 07 August 2015 to 26 March 2021 to document the dynamics and portfolio diversification from a fresh cryptocurrencies-renewable energy perspective. Our time-frequency domain spillovers results reveal that renewable energy stocks are the main spillover contributors in the connectedness system and the short-run spillovers dominate their long-run counterparts. Furthermore, investors can gain more profits through short-run transactions in our portfolio design and we can optimize portfolios by investing a large portion in cryptocurrencies. A fascinating fact is that the COVID-19 pandemic can reverse the effectiveness of our hedging strategy.

The energy security issues of countries along the “Belt and Road” become increasingly important due to the strategic nature of energy resources and prominent ecological damage. The paper analyzed the new development of energy security in the post COVID-19 era, and stated the new challenges in terms of the geopolitical risks, increasing energy market volatility, and energy security governance for the countries along the “Belt and Road”. Finally, the paper put forward countermeasures and suggestions to improve the energy security level of the countries along the “Belt and Road”.

Abstract With the sudden outbreak and rapid spread of COVID-19, global economic development and social stability have been seriously affected. The virus mainly spreads infection among people on a large scale through the air. People are gradually focusing on how to use HVAC system, so that it can play a more efficient and positive role in epidemic prevention and control. Consequently, we designed an intelligent purification and disinfection apparatus for air-conditioning units. The apparatus integrates rapid virus detection and high-efficiency disinfection functions. It uses a modular design and different operating modes for different levels of epidemic periods. This apparatus is not only suitable for daily life, but also can meet the prevention and control requirements during the epidemic period, which takes the economy, energy saving, and environmental protection into account.

PurposeThe purpose of this paper is to explore the internal interaction mechanism of marine scientific research and education, industrial structure upgrading and marine economic growth from a systematic perspective, based on which this work forecasts their future development trends.Design/methodology/approachIn this study, a multivariate grey model is applied to the prediction of marine scientific research and education, industrial structure upgrading and marine economic growth. Considering the impact of the COVID-19 on marine development, this paper introduces the weakening buffer operator into MGM(1,m) and constructs the AWBO-MGM(1,m) model. To verify the validity and accuracy of the new model, this paper uses AWBO-MGM(1,m), MGM(1,m), GM(1,N), GM(1,1), back propagation neural network and linear regression models for simulation and prediction based on the data from 2010 to 2021, respectively.FindingsFrom the theoretical perspective, the development of marine scientific research and education can accelerate industrial upgrading and promote marine economic growth by providing high-quality talents, promoting marine science and technology progress and reducing transaction costs; while the upgrading of marine industrial structure and marine economic growth can promote the development of marine scientific research and education by guiding social capital, enhancing talent demand and stimulating market vitality. From the empirical analysis, the AWBO-MGM(1,m) model can effectively deal with epidemic shocks and has higher fitting and prediction accuracy than the other five comparative models.Practical implicationsThe government should pay attention to the construction of marine scientific research and education, so as to provide high-quality talents and advanced scientific research results for the high-quality development of marine economy. On the basis of using science and technology to firmly build the primary and secondary marine industries, the government should actively guide the labor, capital and other factors of production to the tertiary industry, thereby promoting the optimization and upgrading of marine industrial structure.Originality/valueOn the one hand, the interplay mechanism of marine scientific research and education, industrial structure upgrading and marine economic growth is analyzed from a systematic perspective; on the other hand, the enhanced AWBO-MGM(1,m) possesses higher forecasting performance and is applicable to the systemic multivariate forecasting problem in the presence of outstanding external shocks.

The negative impact of Sino-US trade friction on China and Wuhan’s economy, politics, trade and many other fields is extensive and profound, and the COVID-19’s outbreak has exacerbated this impact. Under these circumstances, this paper analyzes the strategic situation of Wuhan’s service trade based on SWOT analysis. Accordingly, this paper puts forward countermeasures for the innovative development of service trade in Wuhan.

While economic growth has been the main goal of countries around the world, environmental problems such as air pollution have also arisen. Since the increase in economic uncertainty is limiting production capacity and consumers’ marginal propensity to consume, which reduces CO2 emissions, economic policy uncertainty has become one of the most important factors affecting CO2 emissions. COVID-19 has demonstrated that economic policy uncertainty reduces the enthusiasm of market participants, which, in turn, reduces energy demand and CO2 emissions. In order to further study the impact of economic policy uncertainty on air pollution, this study uses a panel model to empirically test the data for a sample of 15 countries covering the period from 1997 to 2019. According to the empirical results, we find that the economic policy uncertainty has a significant negative impact on per capita CO2 emissions. That is, the higher the uncertainty of economic policy, the lower the per capita CO2 emissions of countries. What’s more, this negative effect is larger in emerging market countries than in advanced countries.