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description Publicationkeyboard_double_arrow_right Article 2023Publisher:Frontiers Media SA Authors: Gao, Qingyu; Li, Zhifeng; Zhu, Yuxiang;The accelerator-driven sub-critical system is driven by external neutron sources, which are generated by the spallation reaction and maintain the stable operation of the sub-critical core, while the external neutron source increases the complexity of reactor neutron kinetic processes. This article focuses on simulation analysis of neutron space–time kinetics with a dynamic analysis code, which is developed based on the improved quasi-static approximation and Monte Carlo neutron transport method. The amplitude function and shape functions are solved to achieve the dynamics simulation process. Then, the transient responses of beam interruptions and reactivity insertions are calculated and analyzed for an experimental facility. To further verify the correctness and reliability of dynamic behavior, the simulation results are compared with experimental values, and the results show that the normalized neutron fluxes varying with time are in good agreement with the corresponding values. It can be concluded that the improved quasi-static coupled probability theory method can be used to solve the neutron space–time kinetic problem of the experimental facility, and the results are reliable.
Frontiers in Energy ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert Frontiers in Energy ... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022Publisher:Springer Science and Business Media LLC Funded by:UKRI | Picsima SnugsUKRI| Picsima SnugsThe European Physica... arrow_drop_down The European Physical Journal PlusArticle . 2022 . Peer-reviewedLicense: Springer Nature TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1140/epjp/s13360-022-03493-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert The European Physica... arrow_drop_down The European Physical Journal PlusArticle . 2022 . Peer-reviewedLicense: Springer Nature TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1140/epjp/s13360-022-03493-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1971Publisher:Elsevier BV Authors: Patricia A. Hooper; R. Schneider; Christine J. Benoy;pmid: 5157556
Abstract An orange and an apple juice each containing 250–385 ppm tin were under suspicion of having caused an outbreak of food poisoning in Kuwait in 1967 but did not cause any toxic signs when fed to pigeons, cats and dogs. One cat out of 11 vomited when fed an orange juice containing 540 ppm tin derived from the container, and with juices containing 1370 ppm tin, 20–30% of the cats vomited but none of the dogs was affected. Fruit juices containing 2000 ppm tin caused vomiting in up to 40% of the cats. Modification of orange juices with a high tin content by addition of nitrate or ethanol or by adjustment of the pH from 3 to 6 did not affect the incidence of vomiting. No toxic signs were produced in rats given fruit juices containing added tin salts up to a level of 995 ppm or in rats and cats given aqueous solutions of tin salts (up to 1200 ppm tin) in citric acid. Solid foods containing tin derived from the containers up to the highest level obtainable (470 ppm) had no toxic effect when fed to dogs and cats. Five human volunteers showed no toxic signs after drinking fruit juices containing 498, 540 or 730 ppm tin derived from the containers, but all five had some gastro-intestinal disturbance after drinking a fruit juice containing 1370 ppm tin. A repeat experiment with the latter juice had no effect in four of the volunteers and only mild symptoms in the fifth. In rats and cats, there was no evidence of tin absorption 24 hr after ingestion of fruit juices containing high levels of tin. No tin was recovered from the urine and in the rats 99% was recovered from the faeces. Only minute amounts of tin could be found in the body, apart from the alimentary tract, of a rat that had been given orange juice with a high tin content ad lib. instead of drinking water for 7 days. It is concluded that toxic signs follow the drinking of tin-containing fruit juices by man and cats only with tin levels of approximately 1400 ppm and above, that there is no evidence from these experiments that toxicity is due to the absorption of tin and that the most likely cause is local irritation of the mucous membrane of the alimentary tract.
Food and Cosmetics T... arrow_drop_down Food and Cosmetics ToxicologyArticle . 1971 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0015-6264(71)90152-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu76 citations 76 popularity Top 10% influence Top 10% impulse Average Powered by BIP!
more_vert Food and Cosmetics T... arrow_drop_down Food and Cosmetics ToxicologyArticle . 1971 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0015-6264(71)90152-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2020 United KingdomPublisher:Beilstein Institut Authors:Shahboz Yakubov;
Shahboz Yakubov
Shahboz Yakubov in OpenAIREJoshua P Barham;
Joshua P Barham
Joshua P Barham in OpenAIREThe importance of fluorinated products in pharmaceutical and medicinal chemistry has necessitated the development of synthetic fluorination methods, of which direct C–H fluorination is among the most powerful. Despite the challenges and limitations associated with the direct fluorination of unactivated C–H bonds, appreciable advancements in manipulating the selectivity and reactivity have been made, especially via transition metal catalysis and photochemistry. Where transition metal catalysis provides one strategy for C–H bond activation, transition-metal-free photochemical C–H fluorination can provide a complementary selectivity via a radical mechanism that proceeds under milder conditions than thermal radical activation methods. One exciting development in C–F bond formation is the use of small-molecule photosensitizers, allowing the reactions i) to proceed under mild conditions, ii) to be user-friendly, iii) to be cost-effective and iv) to be more amenable to scalability than typical photoredox-catalyzed methods. In this review, we highlight photosensitized C–H fluorination as a recent strategy for the direct and remote activation of C–H (especially C(sp3)–H) bonds. To guide the readers, we present the developing mechanistic understandings of these reactions and exemplify concepts to assist the future planning of reactions.
Strathprints arrow_drop_down Beilstein Journal of Organic ChemistryArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3762/bjoc.16.183&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 41 citations 41 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Strathprints arrow_drop_down Beilstein Journal of Organic ChemistryArticle . 2020 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3762/bjoc.16.183&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1986Publisher:Emerald Authors: C. Lea;doi: 10.1108/eb043793
For zero‐defect wave soldering of double‐sided and multilayer printed circuit boards, the copper through‐hole‐plating must be impervious to gas generated in the laminate for the period of a few seconds while the solder is molten. The kinetics of the gas evolution during soldering have been related quantitatively to the integrity of the plated copper. This in turn is related to the quality of the electroless copper (evaluated using the backlighting test), the nature and distribution of the catalyst (evaluated using X‐ray photoelectron spectroscopy) and the methods and effectiveness of the hole‐wall preparation (evaluated using scanning electron microscopy). The relevance of laboratory measurements has been confirmed on a wide range of industrial production plating lines.
Circuit World arrow_drop_down Circuit WorldArticle . 1986 . Peer-reviewedLicense: Emerald Insight Site PoliciesData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1108/eb043793&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Average influence Top 10% impulse Average Powered by BIP!
more_vert Circuit World arrow_drop_down Circuit WorldArticle . 1986 . Peer-reviewedLicense: Emerald Insight Site PoliciesData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1108/eb043793&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Journal , Other literature type 2020Embargo end date: 01 Jan 2020 United KingdomPublisher:MDPI AG Authors:Ekaterina Abramova;
Ekaterina Abramova
Ekaterina Abramova in OpenAIREDerek Bunn;
Derek Bunn
Derek Bunn in OpenAIREIntra-day price spreads are of interest to electricity traders, storage and electric vehicle operators. This paper formulates dynamic density functions, based upon skewed-t and similar representations, to model and forecast the German electricity price spreads between different hours of the day, as revealed in the day-ahead auctions. The four specifications of the density functions are dynamic and conditional upon exogenous drivers, thereby permitting the location, scale and shape parameters of the densities to respond hourly to such factors as weather and demand forecasts. The best fitting and forecasting specifications for each spread are selected based on the Pinball Loss function, following the closed-form analytical solutions of the cumulative distribution functions.
CORE arrow_drop_down EnergiesOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/1996-1073/13/3/687/pdfData sources: Multidisciplinary Digital Publishing Institutehttps://dx.doi.org/10.48550/ar...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/en13030687&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert CORE arrow_drop_down EnergiesOther literature type . 2020License: CC BYFull-Text: http://www.mdpi.com/1996-1073/13/3/687/pdfData sources: Multidisciplinary Digital Publishing Institutehttps://dx.doi.org/10.48550/ar...Article . 2020License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/en13030687&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2017 United KingdomPublisher:Elsevier BV Garwood, Tom Lloyd; Hughes, Ben Richard; O'Connor, Dominic; Calautit, John K; Oates, Michael R; Hodgson, Thomas;The industrial sector accounts for 17% of end-use energy in the UK, and 54% globally. Therefore, there is substantial scope for simulating and assessing potential energy retrofit options for industrial buildings. Building Energy Modelling (BEM) applied to industrial buildings poses a complex but important opportunity for reducing global energy demand, due to years of renovation and expansion. Large and complex industrial buildings make modelling existing geometry for BEM difficult and time consuming. This paper presents a potential solution for quickly capturing and processing as-built geometry of a factory to be utilized in BEM. Laser scans were captured from the interior of an industrial facility to produce a Point Cloud. The existing capabilities of a Point Cloud processing software were assessed to identify the potential development opportunities to automate the conversion of Point Clouds to building geometry for BEM applications. In conclusion, scope exists for increasing the speed of 3D geometry creation of an existing industrial building for application in BEM and subsequent thermal simulation.
CORE arrow_drop_down StrathprintsArticle . 2017License: CC BY NC NDData sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.egypro.2017.12.567&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert CORE arrow_drop_down StrathprintsArticle . 2017License: CC BY NC NDData sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.egypro.2017.12.567&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2017 United KingdomPublisher:Elsevier BV Authors:Sally Shahzad;
John Brennan; Dimitris Theodossopoulos; Ben Hughes; +1 AuthorsSally Shahzad
Sally Shahzad in OpenAIRESally Shahzad;
John Brennan; Dimitris Theodossopoulos; Ben Hughes;Sally Shahzad
Sally Shahzad in OpenAIREJohn Kaiser Calautit;
John Kaiser Calautit
John Kaiser Calautit in OpenAIREAbstract Two office layouts with high and low levels of thermal control were compared, respectively traditional cellular and contemporary open plan offices. The traditional Norwegian practice provided every user with control over a window, blinds, door, and the ability to adjust heating and cooling. Occupants were expected to control their thermal environment to find their own comfort, while air conditioning was operating in the background to ensure the indoor air quality. In contrast, in the British open plan office, limited thermal control was provided through openable windows and blinds only for occupants seated around the perimeter of the building. Centrally operated displacement ventilation was the main thermal control system. Users’ perception of thermal environment was recorded through survey questionnaires, empirical building performance through environmental measurements and thermal control through semi-structured interviews. The Norwegian office had 35% higher user satisfaction and 20% higher user comfort compared to the British open plan office. However, the energy consumption in the British practice was within the benchmark and much lower than the Norwegian office. Overall, a balance between thermal comfort and energy efficiency is required, as either extreme poses difficulties for the other.
Applied Energy arrow_drop_down Research at Derby (University of Derby)Article . 2016Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2016.02.100&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu46 citations 46 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Applied Energy arrow_drop_down Research at Derby (University of Derby)Article . 2016Data sources: Bielefeld Academic Search Engine (BASE)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2016.02.100&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2025Publisher:Springer Science and Business Media LLC Funded by:UKRI | EPSRC and NERC Centre for...UKRI| EPSRC and NERC Centre for Doctoral Training in Offshore Wind Energy and the EnvironmentAuthors:Victoria Bessonova;
Merce Casas-Prat; Evdokia Tapoglou; Katharine York; +1 AuthorsVictoria Bessonova
Victoria Bessonova in OpenAIREVictoria Bessonova;
Merce Casas-Prat; Evdokia Tapoglou; Katharine York; Robert Dorrell;Victoria Bessonova
Victoria Bessonova in OpenAIREAbstract In the next 25 years an unprecedented number of new marine artificial structures, over 75,000 offshore wind turbines alone, are planned to meet global net zero targets. Structures are required to last for multiple decades in the hostile marine environment; where the largest cost across their whole lifecycle is on operations and maintenance dependent on accessibility in calm seas. However, the role of climate change on accessibility, and thus operational cost, has not been resolved. Here we provide the first study of future accessibility; evaluated from global climate model driven wave modelling, using the high emission scenario (RCP8.5). We found that climate change drives significant regional variation in accessibility, with the northern hemisphere benefiting from a 6% increase in operating windows whilst accessibility in parts of the southern hemisphere is reduced by 6-9%. These findings will help offshore developers and stakeholders incorporate adaptions to climate change as part of strategic planning practices.
https://doi.org/10.2... arrow_drop_down https://doi.org/10.21203/rs.3....Article . 2025 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-5805411/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert https://doi.org/10.2... arrow_drop_down https://doi.org/10.21203/rs.3....Article . 2025 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-5805411/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1996 United KingdomPublisher:Elsevier BV Authors: Paul M. Kunko;Melisa J. Wallace;
Susan E. Robinson;Melisa J. Wallace
Melisa J. Wallace in OpenAIREpmid: 8981586
The developmental and behavioral effects of prenatal exposure to cocaine and/or ethanol were examined in rats. Pregnant rats received ethanol (E; 2 g/kg, b.i.d.) orally, cocaine (C; 6 mg/kg/day, IV), or both (C/E) on gestational days 8-20. Controls consisted of pair-fed (PF) and untreated (UNT) groups. Offspring were weighed and examined for developmental markers beginning postnatal day one (PD1). On PD21 pups were individually observed in an open-field following either an injection of cocaine (10 mg/kg, IP), an injection of saline, or no treatment. Drug-treated and PF dams ate less food and gained less weight than the UNT dams. C and E litters had slightly increased mortality rates. Pups from both the C and E groups appeared less sensitive to the locomotor stimulant effect of cocaine. Pups from the E group engaged in significantly less spontaneous stereotypic locomotion than UNT and PF pups, while male pups from the C group exhibited a decrease in spontaneous exploratory behavior. Thus, prenatal exposure to C or E altered spontaneous and/or cocaine-induced behavior in weanling-aged rats, while the C/E combination did not augment either effect.
Cronfa at Swansea Un... arrow_drop_down Pharmacology Biochemistry and BehaviorArticle . 1996 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0091-3057(96)00283-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 12 citations 12 popularity Average influence Average impulse Average Powered by BIP!
more_vert Cronfa at Swansea Un... arrow_drop_down Pharmacology Biochemistry and BehaviorArticle . 1996 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0091-3057(96)00283-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu