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Alcoholic liver disease (ALD) is characterized by hepatocyte damage, inflammatory cell activation, and increased intestinal permeability leading to the clinical manifestations of alcoholic hepatitis. Selected members of the family of microRNAs (miRNAs) are affected by alcohol, resulting in an abnormal miRNA profile in the liver and circulation in ALD. Increasing evidence suggests that miRNAs that regulate inflammation, lipid metabolism and promote cancer are affected by excessive alcohol administration in mouse models of ALD. This communication highlights recent findings in miRNA expression and functions as they relate to the pathogenesis of ALD. The cell‐specific distribution of miRNAs, as well as the significance of circulating extracellular miRNAs, is discussed as potential biomarkers. Finally, the prospects of miRNA‐based therapies are evaluated in ALD.

SYNOPSIS In Swaziland policies to alleviate fuelwood shortages have been low on the list of development priorities, as much of the land has extensive bush and tree cover. There are, however, major social and geographical imbalances in biomass resource supply—some areas of Swazi Nation Land are barren due to increasing population pressure and the subsequent demand for fuelwood. This paper will show, in detail, the methodology for the survey which was carried out in Swaziland to investigate the importance of accessibility in linking potential supply to demand. Physical location, land tenure and management practices are generally recognised as important factors to take into consideration when converting potential resources into realistic amounts of fuelwood supply. Guesswork, however, is often used to estimate the impacts of these factors on biomass supplies. A nation-wide study was made in order to obtain more information on the accessibility of resources on privately owned land; results of a household surv...

“Low expectation of success” is proposed as a factor in relation to problem behavior in the comprehensive theoretical model of problem behavior (CTMPB). Based on the framework of CTMPB, this study aimed to further examine the association between confidence in the future (including parental confidence in the adolescent future and adolescent self-confidence in the future in this study) and problem behavior. A nationwide representative sample data from the China Education Panel Survey (CEPS) were used in this study. A total of 8328 middle school students and their parents were included. Among the students, 4081 (49.0%) were boys, the mean age was 14.53 years (SD = 0.70); among the parents, 3908 (46.9%) were male, the mean age was 41.15 years (SD = 5.14). The results reveal that parental confidence in adolescent future (PCAF) can play a role in adolescent problem behavior through adolescent perceived parental confidence in adolescent future (APPCAF) and adolescent self-confidence in the future (ASF). Low levels of both PCAF and ASF are vulnerability risk factors in adolescent problem behavior. Lowering PCAF and ASF might increase the likelihood of engaging in problem behavior. However, this study was based on cross-sectional data only and is required to be supported by further experimental or longitudinal studies.

In recent years, sustainability concerns have gained increasing attention among countries and stakeholders worldwide. Towards the transition to sustainable rural development, the rural web framework (RWF) has become a consistent tool. Indicators from the RWF have been used to explore sustainable rural development for decision-making tasks, which improves the social, economic, and environmental performance of rural regions. However, the application of the RWF in studies is on the decline. Furthermore, there is a lack of literature reviews on the importance of the RWF and its relationship with different facets of sustainable development. We conducted a systematic literature review (SLR) (a) to explore how studies have used the RWF in the context of sustainable development and (b) to identify areas for further research. This study found that the RWF has mostly been used in developed countries, with fewer applications in developing countries. We suggest that there should be increased application of the RWF, particularly in developing countries, to broaden the rural web–sustainable development discourse and its relevance. This paper presents several areas where the indicators of the RWF can be applied to illustrate their relevance for policy decisions towards the achievement of the sustainable development goals (SDGs).

(2002). Electrolytic Deposition (Electroplating) of Metals. Transactions of the IMF: Vol. 80, No. 2, pp. 67-72.

Abstract Catalyst layer structural changes in polymer electrolyte membrane fuel cells have significant impact on the cell performance and durability. In this study, ex-situ experiments are designed to investigate the effect of humidity and/or thermal cycles on the structural changes of catalyst layers. The relative humidity and temperature are controlled by an environmental chamber and the catalyst layer structure is characterized by scanning electron microscopy and optical microscopy. The experimental results indicate that crack growth and development, catalyst agglomerate detachment, and surface bulges are the main structural changes of the catalyst layers. Applying relative humidity and thermal cycling simultaneously causes the most significant crack growth, while applying thermal cycling alone causes no appreciable changes. This indicates that the absolute humidity is the key parameter for the crack growth. Through cyclic voltammetry analysis, it is shown that the electrochemical active surface area decreases from 64.1 m2 g−1 to 49.1 m2 g−1 after 500 combined relative humidity and thermal cycles. Analyses of electrochemical impedance spectroscopy show that the charge transfer resistance and ohmic resistance increase significantly after 500 combined relative humidity and thermal cycles, causing the cell performance degradation.

Background: Minimizing raw salt and increasing fruit consumption are important factors for controlling blood pressure. The study aimed to investigate the following associations: (i) the association between socio-demographic characteristics and awareness of, and attitudes towards, raw salt and fruit consumption and (ii) the association between salt and fruit consumption and blood pressure. Methods: In a cluster-RCT, 307 adults, aged 30 to 75 years, with hypertension were recruited in 2021. Blood pressure was the primary outcome, and knowledge, attitudes and intakes of raw salt and fruit were secondary outcomes. Results: Of the participants, 271 (78.5%) consumed raw salt. More than 80% of the participants knew that reduced raw salt was good for controlling blood pressure and almost everyone knew that fruits and vegetables were good for health. Despite this, 95% of the participants had a habit of eating fruit irregularly. A lower proportion (64%) of the participants having at least a secondary school certificate (SSC) consumed raw salt, compared with those having an education level SSC (82%), p = 0.002. Blood pressure was not significantly different for participants, irrespective of raw salt or fruit consumption. Conclusions: Raw salt consumption among rural people was high and regular fruit consumption was deficient. They intended to reduce raw salt consumption. Appropriate intervention programs should be implemented to reduce salt consumption and increase fruit consumption.

This study investigates the relationship between violent conflict, food price, and climate variability at the subnational level. Using disaggregated data on 113 African markets from January 1997 to April 2010, interrelationships between the three variables are analyzed in simultaneous equation models. We find that: (i) a positive feedback exists between food price and violence - higher food prices increase conflict rates within markets and conflict increases food prices; (ii) anomalously dry conditions are associated with increased frequencies of conflict; and (iii) decreased rainfall exerts an indirect effect on conflict through its impact on food prices. These findings suggest that the negative effects of climate variability on conflict can be mitigated by interventions and effective price management in local markets. Creating environments in which food prices are stable and reliable, and markets are accessible and safe, can lower the impacts of both climate change and conflict feedbacks.