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description Publicationkeyboard_double_arrow_right Article , Journal 2017Publisher:Elsevier BV Authors: Qunwei Wang; Yizhong Wang; P. Zhou; Hongye Wei;Effectively analyzing and then treating energy-related air pollution requires examining every factor, from the pollution source to the end of treatment. This paper applies index decomposition analysis and a whole process treatment perspective to identify the factors facilitating air pollution reduction across three stages: source prevention, process control, and end-of-pipe treatment. Empirical research using data from China’s Jiangsu Province and its 13 cities reveals differences in local approaches to pollution prevention. At the provincial level, end-of-pipe treatment remains the primary approach to control air pollution emissions, indicating that the pattern of “pollute first, govern later” has not yet been fundamentally reversed. At the city level, 13 cities can be divided into four types, based on their approach to air pollution treatment: the leading type, process-dependent type, end-dependent type, and lagging type. Of these, 7 cities are using multiple control approaches, reflecting the comprehensive effect of whole process treatment. The Jiangsu Province should consider further strengthening effective whole process air pollution treatment models, by transitioning to pollution control, adjusting industrial structure, promoting technological progress, and consuming clean energy.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2016.05.073&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu76 citations 76 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2016.05.073&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal , Other literature type 2016Publisher:MDPI AG Authors: Yong Chen; Lihua Zhou;doi: 10.3390/su8111113
This study analyzes farmers’ perception of grazing restriction policies, grassland environment and ecological management following the implementation of environmental protection policies in northern China. Understanding farmers’ attitudes and their causes will hopefully aid in the creation and execution of future policies. One hundred and thirty-five households were surveyed at three occasions over the course of a decade to explore the causes and processes of farmers’ perception. Farmers’ ecological awareness tends to be short term. In areas with a degraded environment, farmers were eager to implement policies to improve the environment and recognized the positive impact of the grazing ban policy (GBP). However, as conditions improved, farmers’ recognition and acceptance of the GBP became negative. Although farmers recognized the benefits of the GBP, they showed little awareness of the long-term process of environmental governance. As can be seen from the farmers’ ecological awareness and their attitudes toward the GBP, they are more inclined to value short-term economic interest than ecological protection. We suggest that good environmental protection policy must take into account the ecological and economic interests of farmers.
Sustainability arrow_drop_down SustainabilityOther literature type . 2016License: CC BYFull-Text: http://www.mdpi.com/2071-1050/8/11/1113/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su8111113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 10 citations 10 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Sustainability arrow_drop_down SustainabilityOther literature type . 2016License: CC BYFull-Text: http://www.mdpi.com/2071-1050/8/11/1113/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su8111113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2018Publisher:Springer Science and Business Media LLC Authors: Gloria Amoruso; Natasha Donevska; Gunstein Skomedal;Buildings in private and domestic use are responsible for about 30% of the global greenhouse gas emissions attributable mainly to their need for heating and cooling energy. This corresponds to about 40% of the global final energy consumption. Therefore, a viable implementation of building energy efficiency policies is inevitable to realize a transformation of the energy system to mitigate climate change. Within the building sector lies a huge potential for emission reduction consisting in the renovation of the existing building stock and climate-friendly building guidelines applicable to new constructions, both adapting CO2-neutral technology solutions. However, as there are several different pathways leading to a decarbonized energy system, there is always the question which political and technological solutions are most efficient, effective, and feasible. This paper aims to analyze building efficiency policy measures and instruments and the related technological solutions in two front-runner countries of the energy transition, possessing different structural conditions: Germany and Norway. We hence apply a comparative approach which allows us to present and assess the policies in place. The paper answers three research questions: (1) Which policies prevail in Germany and Norway to foster the deployment of energy efficient and decarbonized solutions for residential buildings? (2) How do these policies respond to country-specific barriers to the energy transition in the building sector, and (3) What effects do they have on the actual implementation of technological and societal solutions? This research provides a new insight to the highly relevant topic of energy efficiency in buildings in the context of international Intended Nationally Determined Contribution benchmarking and discusses some unsolved trade-offs in the translation of the global climate governance into the national building sector.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12053-018-9637-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu35 citations 35 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12053-018-9637-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008Publisher:Springer Science and Business Media LLC Jianjun Xia; Ye Zhang; Ye Liu; Rong Qin; Jiyi Huang; Ziyan Jiang; Xiaoliang Zhang; Yi Jiang;This is the companion paper of part I of DeST overview. DeST was developed as a building simulation tool with the aim of benefiting both design of and research on building energy efficiency. During its development, DeST has been applied to many projects, development of building regulations, and research. This paper gives examples of several areas in which DeST has been applied, including building design consultation, building commissioning, building energy conservation assessment, a building energy labeling system, and scientific research. Examples from a demonstration building are presented to demonstrate the entire process of aiding design with DeST. Additional projects and regulations are also mentioned to introduce other applications of DeST.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8124-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu95 citations 95 popularity Top 1% influence Top 1% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8124-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 Belgium, SwitzerlandPublisher:SAGE Publications Funded by:EC | ENERGISEEC| ENERGISEAuthors: Henrike Rau; Grégoire Wallenborn; Grégoire Wallenborn; Marlyne Sahakian;This article demonstrates how a cultural reading of consumption that focuses on the meaning and materiality of domestic indoor microclimates can contribute to conceptual developments in the field of practice theory that refocus attention on cultural patterns, including prevailing norms and prescriptions regarding indoor temperature and thermal comfort. Drawing on evidence collected during a research-led change initiative that encouraged people to reduce energy use in the home by lowering indoor temperature to 18°C, we deploy the heuristic device of “indoor microclimate as artifact” to show how the manifestation of this new artifact initiated significant changes in everyday practices that revolve around heating. We observe that these changes may also spill over into the public sphere – from home to workplace. By making the microclimate a tangible and visible thing, we describe how people appropriate and appreciate this new object of consumption, what it says about different bodies in diverse and bounded spaces, and what the artifact as a commodity reveals about broader systems of heating and energy provision, and associated actors. Due to the increasing spread of central heating and the growing importance of complex technological devices to monitor and control indoor temperature, heating is no longer a practice in and of itself for many urban dwellers in Europe. However, when people appropriate the indoor microclimate, new heating-related practices emerge that can lead to energy sufficiency. We thus argue that by deliberately “materializing” domestic indoor microclimate as part of a change initiative, more sustainable forms of energy use can be made to matter.
Cultural Sociology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1749975520932439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Cultural Sociology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1749975520932439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 FrancePublisher:Elsevier BV Rachid Outbib; Daniel Hissel; Daniel Hissel; Stefan Giurgea; Stefan Giurgea; Yongdong Li; Zhongliang Li; Zhongliang Li;This paper proposes a data-driven diagnostic approach for Polymer Electrolyte Membrane Fuel Cell (PEMFC) systems. Fault detection and isolation (FDI) is realized by analyzing individual cell voltages. A feature extraction method Fisher Discriminant Analysis (FDA) and a multi-class classification method Directed Acyclic Graph Support Vector Machine (DAGSVM) are utilized successively to extract the useful features from raw data and classify the extracted features into various classes related to health states. Experimental data of two different stacks are used to validate the proposed approach. The results show that five concerned faults can be detected and isolated with a high accuracy. Moreover, the light computational cost of the approach enhances the possibility of its online implementation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2015.03.076&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu57 citations 57 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2015.03.076&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008Publisher:Springer Science and Business Media LLC Masaya Okumiya; Mika Yoshinaga; Yoshibumi Suigihara; Hideharu Niwa; Hideki Tanaka; Shuzo Murakami; Sanae Namatame; Takeshi Watanabe; Masayasu Ito; Hiromasa Yamaguchi; Yuji Miyajima; Shigeru Tokita; Hideharu Komoda; Katsuhiro Miura; Tetsuji Yasutomo;The importance of LCEM (life cycle energy management) has been recognized from the view of life cycle energy savings for sustainable buildings. The purposes of this research are the proposal of an LCEM framework and development of prototype HVAC system simulation tools for LCEM. In this paper, the necessity of energy simulation tools for LCEM is discussed, and the outline and solution method of the simulation tool are shown.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8209-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8209-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal , Other literature type 2019Publisher:MDPI AG Authors: Cai, Haixia; Fan, Ruguo;doi: 10.3390/su11154093
The energy resource is an essential input of economic growth, which has an important impact on the ecological environment and social welfare. From the perspective of social welfare, considering the radial and non-radial characteristics of different input and output indicators, and the inseparability of the energy input and undesirable output, this study employs the non-separable hybrid DEA (Data Envelopment Analysis) model to evaluate the total energy efficiency of Chinese provinces between 2012 and 2016. Furthermore, this study calculates the energy saving and emission reduction potentials of China. The results reveal that the average total factor energy efficiency in China from 2012 to 2016 is 0.694, which means that there are still 30.6% energy efficiency losses. There is great potential for China to save energy, reduce pollutant emissions, and increase the output of social welfare. There are great differences in the total factor energy efficiency among provinces. The average energy saving potential of the whole country is 60.5%. If the energy efficiency of all provinces can reach the frontier, the whole country can save more than half of the energy consumption. The highest national average emission reduction potential is SO2, followed by dust, CO2, and NOX. The implication of the conclusion is that in the development of regional economy, we cannot sacrifice the social welfare and sustainable development and take the growth rate of GDP as the only objective. Different energy saving and emission reduction policies should be put forward according to the characteristics of different provinces.
Sustainability arrow_drop_down SustainabilityOther literature type . 2019License: CC BYFull-Text: http://www.mdpi.com/2071-1050/11/15/4093/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su11154093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Sustainability arrow_drop_down SustainabilityOther literature type . 2019License: CC BYFull-Text: http://www.mdpi.com/2071-1050/11/15/4093/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su11154093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Journal 2014Embargo end date: 01 Jan 2014 United KingdomPublisher:Elsevier BV Authors: Atif Ansar; Bent Flyvbjerg; Alexander Budzier; Daniel Lunn;A brisk building boom of hydropower mega-dams is underway from China to Brazil. Whether benefits of new dams will outweigh costs remains unresolved despite contentious debates. We investigate this question with the "outside view" or "reference class forecasting" based on literature on decision-making under uncertainty in psychology. We find overwhelming evidence that budgets are systematically biased below actual costs of large hydropower dams - excluding inflation, substantial debt servicing, environmental, and social costs. Using the largest and most reliable reference data of its kind and multilevel statistical techniques applied to large dams for the first time, we were successful in fitting parsimonious models to predict cost and schedule overruns. The outside view suggests that in most countries large hydropower dams will be too costly in absolute terms and take too long to build to deliver a positive risk-adjusted return unless suitable risk management measures outlined in this paper can be affordably provided. Policymakers, particularly in developing countries, are advised to prefer agile energy alternatives that can be built over shorter time horizons to energy megaprojects.
Energy Policy arrow_drop_down https://dx.doi.org/10.48550/ar...Article . 2014License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.10.069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 535 citations 535 popularity Top 0.1% influence Top 0.1% impulse Top 0.1% Powered by BIP!
more_vert Energy Policy arrow_drop_down https://dx.doi.org/10.48550/ar...Article . 2014License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.10.069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021Publisher:American Chemical Society (ACS) Jingyi Yang; Xiaoyuan Lin; Na Xing; Zhao Zhang; Haiwei Zhang; Haibo Wu; Weiwei Xue;pmid: 34279924
The continual spread of novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posing a severe threat to the health worldwide. The main protease (Mpro, alias 3CLpro) of SARS-CoV-2 is a crucial enzyme for the maturation of viral particles and is a very attractive target for designing drugs to treat COVID-19. Here, we propose a multiple conformation-based virtual screening strategy to discover inhibitors that can target SARS-CoV-2 Mpro. Based on this strategy, nine Mpro structures and a protein mimetics library with 8960 commercially available compounds were prepared to carry out ensemble docking for the first time. Five of the nine structures are apo forms presented in different conformations, whereas the other four structures are holo forms complexed with different ligands. The surface plasmon resonance assay revealed that 6 out of 49 compounds had the ability to bind to SARS-CoV-2 Mpro. The fluorescence resonance energy transfer experiment showed that the biochemical half-maximal inhibitory concentration (IC50) values of the six compounds could hamper Mpro activities ranged from 0.69 ± 0.05 to 2.05 ± 0.92 μM. Evaluation of antiviral activity using the cell-based assay indicated that two compounds (Z1244904919 and Z1759961356) could strongly inhibit the cytopathic effect and reduce replication of the living virus in Vero E6 cells with the half-maximal effective concentrations (EC50) of 4.98 ± 1.83 and 8.52 ± 0.92 μM, respectively. The mechanism of the action for the two inhibitors were further elucidated at the molecular level by molecular dynamics simulation and subsequent binding free energy analysis. As a result, the discovered noncovalent reversible inhibitors with novel scaffolds are promising antiviral drug candidates, which may be used to develop the treatment of COVID-19.
Smithsonian figshare arrow_drop_down Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Journal of Chemical Information and ModelingArticle . 2021 . Peer-reviewedLicense: https://doi.org/10.15223/policy-001Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.jcim.1c00355&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 61 citations 61 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Smithsonian figshare arrow_drop_down Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Journal of Chemical Information and ModelingArticle . 2021 . Peer-reviewedLicense: https://doi.org/10.15223/policy-001Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.jcim.1c00355&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Journal 2017Publisher:Elsevier BV Authors: Qunwei Wang; Yizhong Wang; P. Zhou; Hongye Wei;Effectively analyzing and then treating energy-related air pollution requires examining every factor, from the pollution source to the end of treatment. This paper applies index decomposition analysis and a whole process treatment perspective to identify the factors facilitating air pollution reduction across three stages: source prevention, process control, and end-of-pipe treatment. Empirical research using data from China’s Jiangsu Province and its 13 cities reveals differences in local approaches to pollution prevention. At the provincial level, end-of-pipe treatment remains the primary approach to control air pollution emissions, indicating that the pattern of “pollute first, govern later” has not yet been fundamentally reversed. At the city level, 13 cities can be divided into four types, based on their approach to air pollution treatment: the leading type, process-dependent type, end-dependent type, and lagging type. Of these, 7 cities are using multiple control approaches, reflecting the comprehensive effect of whole process treatment. The Jiangsu Province should consider further strengthening effective whole process air pollution treatment models, by transitioning to pollution control, adjusting industrial structure, promoting technological progress, and consuming clean energy.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2016.05.073&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu76 citations 76 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2016.05.073&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal , Other literature type 2016Publisher:MDPI AG Authors: Yong Chen; Lihua Zhou;doi: 10.3390/su8111113
This study analyzes farmers’ perception of grazing restriction policies, grassland environment and ecological management following the implementation of environmental protection policies in northern China. Understanding farmers’ attitudes and their causes will hopefully aid in the creation and execution of future policies. One hundred and thirty-five households were surveyed at three occasions over the course of a decade to explore the causes and processes of farmers’ perception. Farmers’ ecological awareness tends to be short term. In areas with a degraded environment, farmers were eager to implement policies to improve the environment and recognized the positive impact of the grazing ban policy (GBP). However, as conditions improved, farmers’ recognition and acceptance of the GBP became negative. Although farmers recognized the benefits of the GBP, they showed little awareness of the long-term process of environmental governance. As can be seen from the farmers’ ecological awareness and their attitudes toward the GBP, they are more inclined to value short-term economic interest than ecological protection. We suggest that good environmental protection policy must take into account the ecological and economic interests of farmers.
Sustainability arrow_drop_down SustainabilityOther literature type . 2016License: CC BYFull-Text: http://www.mdpi.com/2071-1050/8/11/1113/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su8111113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 10 citations 10 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Sustainability arrow_drop_down SustainabilityOther literature type . 2016License: CC BYFull-Text: http://www.mdpi.com/2071-1050/8/11/1113/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su8111113&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2018Publisher:Springer Science and Business Media LLC Authors: Gloria Amoruso; Natasha Donevska; Gunstein Skomedal;Buildings in private and domestic use are responsible for about 30% of the global greenhouse gas emissions attributable mainly to their need for heating and cooling energy. This corresponds to about 40% of the global final energy consumption. Therefore, a viable implementation of building energy efficiency policies is inevitable to realize a transformation of the energy system to mitigate climate change. Within the building sector lies a huge potential for emission reduction consisting in the renovation of the existing building stock and climate-friendly building guidelines applicable to new constructions, both adapting CO2-neutral technology solutions. However, as there are several different pathways leading to a decarbonized energy system, there is always the question which political and technological solutions are most efficient, effective, and feasible. This paper aims to analyze building efficiency policy measures and instruments and the related technological solutions in two front-runner countries of the energy transition, possessing different structural conditions: Germany and Norway. We hence apply a comparative approach which allows us to present and assess the policies in place. The paper answers three research questions: (1) Which policies prevail in Germany and Norway to foster the deployment of energy efficient and decarbonized solutions for residential buildings? (2) How do these policies respond to country-specific barriers to the energy transition in the building sector, and (3) What effects do they have on the actual implementation of technological and societal solutions? This research provides a new insight to the highly relevant topic of energy efficiency in buildings in the context of international Intended Nationally Determined Contribution benchmarking and discusses some unsolved trade-offs in the translation of the global climate governance into the national building sector.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12053-018-9637-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu35 citations 35 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12053-018-9637-5&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008Publisher:Springer Science and Business Media LLC Jianjun Xia; Ye Zhang; Ye Liu; Rong Qin; Jiyi Huang; Ziyan Jiang; Xiaoliang Zhang; Yi Jiang;This is the companion paper of part I of DeST overview. DeST was developed as a building simulation tool with the aim of benefiting both design of and research on building energy efficiency. During its development, DeST has been applied to many projects, development of building regulations, and research. This paper gives examples of several areas in which DeST has been applied, including building design consultation, building commissioning, building energy conservation assessment, a building energy labeling system, and scientific research. Examples from a demonstration building are presented to demonstrate the entire process of aiding design with DeST. Additional projects and regulations are also mentioned to introduce other applications of DeST.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8124-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu95 citations 95 popularity Top 1% influence Top 1% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8124-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2020 Belgium, SwitzerlandPublisher:SAGE Publications Funded by:EC | ENERGISEEC| ENERGISEAuthors: Henrike Rau; Grégoire Wallenborn; Grégoire Wallenborn; Marlyne Sahakian;This article demonstrates how a cultural reading of consumption that focuses on the meaning and materiality of domestic indoor microclimates can contribute to conceptual developments in the field of practice theory that refocus attention on cultural patterns, including prevailing norms and prescriptions regarding indoor temperature and thermal comfort. Drawing on evidence collected during a research-led change initiative that encouraged people to reduce energy use in the home by lowering indoor temperature to 18°C, we deploy the heuristic device of “indoor microclimate as artifact” to show how the manifestation of this new artifact initiated significant changes in everyday practices that revolve around heating. We observe that these changes may also spill over into the public sphere – from home to workplace. By making the microclimate a tangible and visible thing, we describe how people appropriate and appreciate this new object of consumption, what it says about different bodies in diverse and bounded spaces, and what the artifact as a commodity reveals about broader systems of heating and energy provision, and associated actors. Due to the increasing spread of central heating and the growing importance of complex technological devices to monitor and control indoor temperature, heating is no longer a practice in and of itself for many urban dwellers in Europe. However, when people appropriate the indoor microclimate, new heating-related practices emerge that can lead to energy sufficiency. We thus argue that by deliberately “materializing” domestic indoor microclimate as part of a change initiative, more sustainable forms of energy use can be made to matter.
Cultural Sociology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1749975520932439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Cultural Sociology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/1749975520932439&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 FrancePublisher:Elsevier BV Rachid Outbib; Daniel Hissel; Daniel Hissel; Stefan Giurgea; Stefan Giurgea; Yongdong Li; Zhongliang Li; Zhongliang Li;This paper proposes a data-driven diagnostic approach for Polymer Electrolyte Membrane Fuel Cell (PEMFC) systems. Fault detection and isolation (FDI) is realized by analyzing individual cell voltages. A feature extraction method Fisher Discriminant Analysis (FDA) and a multi-class classification method Directed Acyclic Graph Support Vector Machine (DAGSVM) are utilized successively to extract the useful features from raw data and classify the extracted features into various classes related to health states. Experimental data of two different stacks are used to validate the proposed approach. The results show that five concerned faults can be detected and isolated with a high accuracy. Moreover, the light computational cost of the approach enhances the possibility of its online implementation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2015.03.076&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu57 citations 57 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.apenergy.2015.03.076&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2008Publisher:Springer Science and Business Media LLC Masaya Okumiya; Mika Yoshinaga; Yoshibumi Suigihara; Hideharu Niwa; Hideki Tanaka; Shuzo Murakami; Sanae Namatame; Takeshi Watanabe; Masayasu Ito; Hiromasa Yamaguchi; Yuji Miyajima; Shigeru Tokita; Hideharu Komoda; Katsuhiro Miura; Tetsuji Yasutomo;The importance of LCEM (life cycle energy management) has been recognized from the view of life cycle energy savings for sustainable buildings. The purposes of this research are the proposal of an LCEM framework and development of prototype HVAC system simulation tools for LCEM. In this paper, the necessity of energy simulation tools for LCEM is discussed, and the outline and solution method of the simulation tool are shown.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8209-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu6 citations 6 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12273-008-8209-6&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal , Other literature type 2019Publisher:MDPI AG Authors: Cai, Haixia; Fan, Ruguo;doi: 10.3390/su11154093
The energy resource is an essential input of economic growth, which has an important impact on the ecological environment and social welfare. From the perspective of social welfare, considering the radial and non-radial characteristics of different input and output indicators, and the inseparability of the energy input and undesirable output, this study employs the non-separable hybrid DEA (Data Envelopment Analysis) model to evaluate the total energy efficiency of Chinese provinces between 2012 and 2016. Furthermore, this study calculates the energy saving and emission reduction potentials of China. The results reveal that the average total factor energy efficiency in China from 2012 to 2016 is 0.694, which means that there are still 30.6% energy efficiency losses. There is great potential for China to save energy, reduce pollutant emissions, and increase the output of social welfare. There are great differences in the total factor energy efficiency among provinces. The average energy saving potential of the whole country is 60.5%. If the energy efficiency of all provinces can reach the frontier, the whole country can save more than half of the energy consumption. The highest national average emission reduction potential is SO2, followed by dust, CO2, and NOX. The implication of the conclusion is that in the development of regional economy, we cannot sacrifice the social welfare and sustainable development and take the growth rate of GDP as the only objective. Different energy saving and emission reduction policies should be put forward according to the characteristics of different provinces.
Sustainability arrow_drop_down SustainabilityOther literature type . 2019License: CC BYFull-Text: http://www.mdpi.com/2071-1050/11/15/4093/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su11154093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!
more_vert Sustainability arrow_drop_down SustainabilityOther literature type . 2019License: CC BYFull-Text: http://www.mdpi.com/2071-1050/11/15/4093/pdfData sources: Multidisciplinary Digital Publishing Instituteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/su11154093&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Journal 2014Embargo end date: 01 Jan 2014 United KingdomPublisher:Elsevier BV Authors: Atif Ansar; Bent Flyvbjerg; Alexander Budzier; Daniel Lunn;A brisk building boom of hydropower mega-dams is underway from China to Brazil. Whether benefits of new dams will outweigh costs remains unresolved despite contentious debates. We investigate this question with the "outside view" or "reference class forecasting" based on literature on decision-making under uncertainty in psychology. We find overwhelming evidence that budgets are systematically biased below actual costs of large hydropower dams - excluding inflation, substantial debt servicing, environmental, and social costs. Using the largest and most reliable reference data of its kind and multilevel statistical techniques applied to large dams for the first time, we were successful in fitting parsimonious models to predict cost and schedule overruns. The outside view suggests that in most countries large hydropower dams will be too costly in absolute terms and take too long to build to deliver a positive risk-adjusted return unless suitable risk management measures outlined in this paper can be affordably provided. Policymakers, particularly in developing countries, are advised to prefer agile energy alternatives that can be built over shorter time horizons to energy megaprojects.
Energy Policy arrow_drop_down https://dx.doi.org/10.48550/ar...Article . 2014License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.10.069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 535 citations 535 popularity Top 0.1% influence Top 0.1% impulse Top 0.1% Powered by BIP!
more_vert Energy Policy arrow_drop_down https://dx.doi.org/10.48550/ar...Article . 2014License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.enpol.2013.10.069&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021Publisher:American Chemical Society (ACS) Jingyi Yang; Xiaoyuan Lin; Na Xing; Zhao Zhang; Haiwei Zhang; Haibo Wu; Weiwei Xue;pmid: 34279924
The continual spread of novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posing a severe threat to the health worldwide. The main protease (Mpro, alias 3CLpro) of SARS-CoV-2 is a crucial enzyme for the maturation of viral particles and is a very attractive target for designing drugs to treat COVID-19. Here, we propose a multiple conformation-based virtual screening strategy to discover inhibitors that can target SARS-CoV-2 Mpro. Based on this strategy, nine Mpro structures and a protein mimetics library with 8960 commercially available compounds were prepared to carry out ensemble docking for the first time. Five of the nine structures are apo forms presented in different conformations, whereas the other four structures are holo forms complexed with different ligands. The surface plasmon resonance assay revealed that 6 out of 49 compounds had the ability to bind to SARS-CoV-2 Mpro. The fluorescence resonance energy transfer experiment showed that the biochemical half-maximal inhibitory concentration (IC50) values of the six compounds could hamper Mpro activities ranged from 0.69 ± 0.05 to 2.05 ± 0.92 μM. Evaluation of antiviral activity using the cell-based assay indicated that two compounds (Z1244904919 and Z1759961356) could strongly inhibit the cytopathic effect and reduce replication of the living virus in Vero E6 cells with the half-maximal effective concentrations (EC50) of 4.98 ± 1.83 and 8.52 ± 0.92 μM, respectively. The mechanism of the action for the two inhibitors were further elucidated at the molecular level by molecular dynamics simulation and subsequent binding free energy analysis. As a result, the discovered noncovalent reversible inhibitors with novel scaffolds are promising antiviral drug candidates, which may be used to develop the treatment of COVID-19.
Smithsonian figshare arrow_drop_down Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Journal of Chemical Information and ModelingArticle . 2021 . Peer-reviewedLicense: https://doi.org/10.15223/policy-001Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.jcim.1c00355&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 61 citations 61 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert Smithsonian figshare arrow_drop_down Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Smithsonian figshareArticle . 1753License: CC BY NCData sources: Bielefeld Academic Search Engine (BASE)Journal of Chemical Information and ModelingArticle . 2021 . Peer-reviewedLicense: https://doi.org/10.15223/policy-001Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1021/acs.jcim.1c00355&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu