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Preconditioning brain cultures with moderate concentrations of ethanol (EtOH) or trans-resveratrol (RES), key red wine constituents, can prevent amyloid-β (Aβ) neurotoxicity. Past studies have indicated that moderate EtOH activates synaptic N-methyl-D-aspartate receptors (NMDAR) that, in part, signal via protein kinase C (PKC) to increase protective antioxidant proteins such as peroxiredoxin-2 (Prx2). RES preconditioning also is reported to involve NMDAR and PKC. However, although moderate, the EtOH and RES concentrations used have been noticeably above circulating levels from two glasses of wine, a daily intake linked to reduced risk of cognitive decline among older social drinkers. Given their mechanistic parallels, we speculated that subprotective EtOH and RES concentrations in a combinatorial preconditioning paradigm might elicit synergistic neuroprotection. To examine this notion, rat cerebellar cultures were pretreated with 10 mM EtOH (circulating concentration after ~ 2 drinks), 5 μM RES, EtOH + RES combinatorially, or media alone (controls). After 3 days, media were removed, and fresh media aliquots containing Aβ25-35 (25 μM) were added. Assessing apoptosis 24 h later with Hoescht 33342, neurodegeneration did not differ from controls in cultures separately preconditioned with 10 mM EtOH or 5 μM RES. However, apoptosis was prevented in combinatorially preconditioned cultures. Also, immunoblotting revealed elevated Prx2 levels due to combinatorial pretreatment that correlated with subsequent neuroprotection, whereas Prx2 was unchanged in separately pretreated cultures. Although the protective mechanisms require clarification, synergistically upregulated NMDAR-PKC-Prx2 (and other antioxidant proteins) is a reasonable component. These findings imply that EtOH + RES antioxidant synergy could be involved in neurobenefits attributed to low-moderate wine consumption.

Abstract The accurate prediction of heat transfer deterioration (HTD) is important to ensure the safe operation of scCO2 cycles driven by various heat sources. Here, the scCO2 heat transfer experiment is performed in a 10 mm diameter vertical tube, covering the ranges of pressures 7.51–21.1 MPa, mass fluxes 488–1500 kg/m2s and heat fluxes 43.7–488 kW/m2. Both uniform heating and non-uniform heating cases are dealt with, but more attention is paid on non-uniform heating. We show that non-uniform heating displays strong circumference angles dependent heat transfer characteristic. Normal heat transfer (NHT) displays gentle rise of wall temperatures along flow length, but for HTD, wall temperature peak is detected ahead of pseudo-critical point. Pseudo-boiling is introduced to deal with scCO2 heat transfer. Heat added to scCO2 is decoupled into a temperature rise part and a phase change part. Flow structure includes a vapor-like fluid near tube wall and a liquid-like fluid in tube core. The analogy between subcritical boiling and supercritical heat transfer results in a supercritical-boiling-number SBO to govern the vapor layer thickness. Sudden change from NHT to HTD is found when crossing a critical SBOcr, which is 5.126 × 10−4 for uniform heating based on our experimental data and other data in the literature, but becomes 8.908 × 10−4 for non-uniform heating using our experimental data. Compared to uniform heating, non-uniform heating is found to delay the occurrence of HTD. The criterion presented here is useful to avoid the occurrence of HTD in the design and operation of scCO2 cycles.

Microcystis development in most temperate lakes shows an annual cycle that is mainly triggered by water temperature and includes four stages. This study aims to identify the optimum growth temperature and the temperature thresholds for recruitment and overwintering in Microcystis in Lake Taihu, based on field data and experiments at the cellular and genetic level on Microcystis under a simulated temperature condition. The field investigation showed that the cyanobacterial biomass began to increase at 11-15 °C in spring, reached a peak at 20-30 °C and remained at a low level after the water temperature declined below 6 °C. The simulation experiment found that the recovery of gene expression, photosynthesis and growth in Microcystis cells occurred at 11-14 °C and increased to an appreciable level after the temperature exceeded 20 °C. Microcystis cells stopped growing and maintained low photosynthetic activity and gene expression when the temperature declined to 10 °C or lower. These results suggest that Microcystis in Lake Taihu begin recruitment at 11-14 °C in spring and grow vigorously at 20-30 °C, then overwinter at 10 °C or lower in winter.

Abstract Methane is responsible for 20% of the global warming resulting from greenhouse gas emissions. Municipal solid waste (MSW) landfills are the third largest anthropogenic source of methane and are thus important to estimating the global methane budget and evaluating its contribution to global greenhouse gas emissions. Based on the greenhouse gas inventory guidelines from the Intergovernmental Panel on Climate Change (IPCC) and the first-order decay method used to estimate emissions from MSW landfills – and in line with MSW management in various regions – we calculated methane emissions from MSW landfills in various Chinese provinces from 2003 to 2013. During this period, methane emissions from MSW landfills increased from 1141.10 Gg to 1858.98 Gg, representing a mean annual increase of 71.79 Gg. MSW emissions tended to increase more in the northern and western provinces than in the southern and eastern provinces, as methane emissions strongly and positively correlated with population and socioeconomic demographics. MSW decontamination is growing rapidly in China, and landfills predominate in all MSW treatments; moreover, incineration has also dramatically increased in recent years.

Applicable anode with an industrial‐compatible production process, high capacitance, and good stability is of great importance for the development of lithium‐ion battery technology. In this work, a composite of carbon/silicon with a well‐reserved void is prepared. The composite shows uniform spherical morphology with rich inside voids between the silicon core and carbon shell. Benefiting from the porous structure, the volumetric variation of silicon in the composite as anode during the charging/discharging process can be reversible, and its good anode stability can be achieved in comparison with carbon‐coated silicon without void. The gravimetric capacitance of it reaches 1579.5 mAh g−1. After 100 cycles, the capacitance retention achieves 91.7% compared with 79.8% of carbon‐coated silicon without void.

Abstract Micro combustor acts as the most important component of the micro thermo photovoltaic (TPV) system. It is crucial that the design and performance of a micro combustor are optimized for its application in a micro TPV system. A micro combustor with front-cavity is proposed in this study, and comparisons of flame stability and thermal performance of the micro combustor with and without front-cavity are made. In addition, the effects of front-cavity size and front-cavity shape on OH mass fraction, flame location and thermal performance of micro combustor are also discussed. The front-cavity in the micro combustor helps to improve the flame stability, increase outer wall temperature value and total energy conversion efficiency for the micro TPV system. It is found that the micro combustor with arc front-cavity (inner diameter ratio of front-cavity and combustion chamber is β = 0.9) is more suitable for the application in the micro TPV system.

Hot flue gas evaporation technology is an effective strategy for zero liquid discharge of desulfurization wastewater. However, there is a potential risk that heavy metals such as Hg may be released from the wastewater during evaporation, disrupting the original balance of the power plant or even exceeding the Hg emission standard. Wastewater evaporation and Hg release behavior were obtained using a single droplet drying system. At an evaporation temperature of 300 °C, approximately 18.5% of Hg was released in the constant wet-bulb temperature period, and the remaining was released in the following evaporation periods. Furthermore, a fixed-bed experiment, in combination with density functional theory calculations, was used to investigate the possible migration mechanisms of released Hg. The results revealed that high HCl concentration, introduced fly ash, and precipitated evaporation products play a crucial role in the fate of Hg, and 85.3% of Hg finally turned into less harmful particulate-bound Hg. This study provides a new and effective strategy for evaluating the migration process of pollutants in wastewater treatment. Moreover, it will serve as an essential reference for advanced wastewater treatment and heavy metals control technologies in the future.