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Nowadays, quality of life and livability are controversial phenomenon. A high quality of life and livability are demanded in cities; however, rapid and unplanned urbanization creates a lot of challenges such as poverty, slums, social instability, insecurity, diseases, environmental challenges and climate change, unemployment, economic problems, etc., which threaten the livability of the world. Therefore, it is vital to tackle urbanization challenges and create a sustainable urban setting with a high quality of life in order to make the world a better place to live. In particular, literature reviews, surveys, exploratory case studies, and the Kiwi and Kampenhood methodology based on Persian Zarathustra that is utilized in social science, engineering and management are the main method tools in this study. Fundamentally, modern livable and sustainable urban settings are suggested as a path to deal with urbanization challenges in order to improve livability and quality of life. Although sustainable cities provide opportunities to improve quality of life, urban planning and good governance with effective regulatory frameworks to create such modern settings are required. Thus, an innovative sustainable project management is introduced as a tool to design modern livable and sustainable areas. Innovation is declared as an accelerator to achieve sustainable project management in this research.

Anatoxin-a is one of the common and major cyanobacterial neurotoxins acting as a powerful agonist at nicotinic acetylcholine receptors (nAChR). In recent years, the toxin has become the focus of public attention, due to the mass development of cyanobacteria (cyanobacterial blooms) in freshwater bodies triggered by eutrophication and climate change. Anatoxin-a is suspected to have a distinct toxic mechanism depending on physiological and nervous systems in exposed organisms. The numerous researches have been actively conducted with respect to the toxic effects of anatoxin-a on mammals; however, little research has aimed at its possible effects on aquatic plants, wherein well-structured nervous system is absent with the lack of various components of the acetylcholine mechanism. In this study, submerged macrophyte Ceratophyllum demersum (C. demersum) was adopted to examine the effects of anatoxin-a on morphological (growth), physiological (photosynthetic pigment contents) and biochemical (hydrogen peroxide level, biotransformation and antioxidative enzymes) responses in the aquatic plant at environmentally relevant concentrations (0.005, 0.05, 0.5, 5 and 50 μg/L). The significant elevation of antioxidative enzymes in parallel with increased formation of hydrogen peroxide appeared from 0.5 μg/L of anatoxin-a. In the measurement of photosynthetic pigments, the decrease in chlorophyll a content was detected at 5 and 50 μg/L, whereas the increase in carotenoids/total chlorophyll was observed from 0.05 μg/L. Accordingly, the alteration in growth was manifested in the presence of 5 and 50 μg/L of anatoxin-a. The results clearly indicate that anatoxin-a can disrupt homeostasis of C. demersum through induction of oxidative stress; furthermore this aquatic plant possesses effective defense mechanisms to cope with low concentrations of anatoxin-a.

Abnormal sensory perception is among the earliest symptoms of autism spectrum disorders (ASD). Despite mixed findings, olfactory perception seems to be altered in ASD. There is also evidence that automatic responses to odours can serve as biomarkers of ASD. However, this potential use of odour-based biomarkers for ASD is still underexplored. In this study, we aimed to investigate whether physiological responses to social and non-social odours, measured with electrocardiography (ECG) and facial electromyography (EMG), can be used to characterise and predict ASD in adults. For that, we extracted 32 signal features from a previously collected database of 11 adults with ASD and 48 adults with typical development (TD). Firstly, non-parametric tests were performed, showing significant differences between the ASD and the TD groups in 10 features. Secondly, a k-nearest-neighbour classifier with a leave-one-out strategy was employed, obtaining an F1-score of 67%. Although caution is needed due to the small sample size, this study provides preliminary evidence supporting the use of physiological responses to social and non-social odours as a potential diagnostic tool for ASD in adults.

The development of physical culture and sports is one of the most important tasks that the state solves in the course of its regulatory and financing activities. This is facilitated by increasing the sports authority of the state on the world stage, increasing the life expectancy and physical health of a person. However, this task is also directly related to the dependence of the population's quality of life on physical activity and human health. At the turn of the 20th and 21st centuries, the problem of physical and moral health of the population has worsened in many countries. This was due to an increase in various adverse economic, environmental and social factors. This article discusses the development of physical culture and sports as a method of measuring and improving the quality of life of the population, solving the problem of human life expectancy. Analyzing and comparing the experience of different countries, we will find a direct and indirect relationship between the physical health of the population and their quality of life. The study is based on official documents of the Russian Federation and news sources that will allow you to track the financing of the physical culture sector, its results and impact on the lives of the population of certain countries.

There is much discussion on the non-linear relationship between economic growth and carbon dioxide (CO2) emissions. Additionally, the effects of Foreign Direct Investment (FDI) on the environment are ambiguous, as both beneficial (i.e., pollution-halo) and harmful (i.e., pollution-haven) effects were found. Therefore, the literature presents no consensus on either of these topics. This is especially problematic for developing regions, as these regions represent growing economies interested in receiving foreign investments, and their CO2-related research is limited. This study aims to understand the impacts of economic growth and FDI on the CO2 emissions of São Paulo state, Brazil. To perform this study, a unique dataset on regional FDI was built, and 592 municipalities were included. The analyses combine linear and non-linear estimations, and the results suggest a non-linear relationship between Gross Domestic Product (GDP) per capita and CO2 emissions, along with a negative association between FDI and CO2. Finally, this study discusses possible policy implications and contributes to the international literature.

This systematic review assembles evidence for rights-based approaches–the right to food and food sovereignty–for achieving food security and adequate nutrition (FSN). We evaluated peer-reviewed and gray literature produced between 1992 and 2018 that documents empirical relationships between the right to food or food sovereignty and FSN. We classified studies by literature type, study region, policy approach (food sovereignty or right to food) and impact (positive, negative, neutral, and reverse-positive) on FSN. To operationalize the concepts of food sovereignty and the right to food and connect them to the tangible interventions and practices observed in each reviewed study, we also classified studies according to 11 action types theorized to have an impact on FSN; these included “Addressing inequities in land access and confronting the process of land concentration” and “Promoting gender equity,” among others. We found strong evidence from across the globe indicating that food sovereignty and the right to food positively influence FSN outcomes. A small number of documented cases suggest that narrow rights-based policies or interventions are insufficient to overcome larger structural barriers to realizing FSN, such as inequitable land policy or discrimination based on race, gender or class.

The activities of the 5'I-deiodinase (5'D-I), 5'II deiodinase (5'D-II) and 5III-deiodinase (5D-III) isoenzymes and tissue concentrations of thyroxine (T4) and triiodothyronine (T3) were measured in up to 10 regions of the rat brain after acute and subchronic nonpharmacological (sleep deprivation, 12 h fasting, 14 days' calorie-reduced diet) and pharmacological (ethanol, haloperidol, clozapine, lithium, carbamazepine, desipramine, fluoxetine, tranylcypromine, and mianserin) treatments. All of these treatments induced significant and sometimes dramatic changes in 5'D-II activities and tissue concentrations of thyroid hormones and, to a lesser extent, in 5D-III activity. The activity of 5'D-I remained unaffected. The results revealed a surprising specificity for each type of treatment in terms of the isoenzyme and hormone affected, the direction of the change, the brain region affected and the time of day. The changes in thyroid hormone concentrations frequently failed to correspond in any way to those in deiodinase activities and unexpected effects such as inhibition of both 5'D-II and 5D-III were seen, indicating that there may be additional pathways of iodothyronine metabolism in the CNS. In conclusion, particularly 5'D-II activity and thyroid hormone concentrations in the CNS are highly sensitive to many different kinds of influence that may induce changes in neuronal activity. However, these changes in deiodinase activities do not ensure stable tissue concentrations of T3, but were, on the contrary, in most cases accompanied by marked changes T3 levels in the tissue. The implications of these findings for the physiological role of thyroid hormones in the CNS are discussed.

Mouthwash ingestion has been observed in settings of restricted availability to alcoholic beverages such as in hospitals, prisons or military establishments. The literature offers limited evidence that ingredients of mouthwash may have health effects above the effects of ethanol. This study provides a quantitative risk assessment based on analysis of 30 mouthwash samples. All investigated brands contained alcohol, most of them menthol (93%), eucalyptol (90%), benzoic acid (87%), methyl salicylate (67%), and thymol (30%). For low risk drinking scenarios with average levels, only ethanol will exceed acceptable daily intakes (ADI). In worst case scenarios for alcohol dependent consumers ingesting 100g ethanol per day in the form of mouthwash, methyl salicylate will also exceeded the ADI by a factor of 17. The margin of exposure (MOE) for methyl salicylate, benzoates and thymol was below 100 for average scenarios, and below 10 for worst case scenarios, but ethanol is still the most toxic ingredient with MOE below 1. The occasional or even chronic ingestion of mouthwash may not cause health effects except the effects of ethanol alone. Only in extreme exposures, ingredients such as thymol or methyl salicylate could exacerbate the effects of ethanol, especially by contributing to metabolic acidosis.