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Abstract The study was designed to analyse the protective effects of almagate on a model of gastric injury, ethanol-induced mucosal damage, in which acid plays little, if any, role. Pretreatment with almagate dose-dependently reduced the level of gastric damage induced by oral administration of 1mL 100% ethanol. Administration of 12 μmol kg−1 almagate 30 min before ethanol significantly reduced the area of mucosal damage by 65 ± 10%, and the maximum level of inhibition (74 ± 11%) was obtained with 150 μmol kg−1 almagate. Administration of higher doses of almagate (200–250 μmol kg−1) did not result in any further increase in the level of protection against ethanol-induced gastric damage. Administration of 1 mL 100% ethanol induces substantial damage to the gastric mucosa, with nearly 40% of the length of the section evaluated exhibiting deep necrotic and haemorrhagic damage. Pretreatment with almagate caused a significant diminution in all parameters of histological damage, whereas damage to the epithelial cell layer was only significantly reduced by pretreatment with the highest doses evaluated (25, 50 and 150 μmol kg−1). Administration of aluminium hydroxide did not modify ethanol-induced mucosal damage, even at doses containing concentrations of aluminium higher than those present in gastroprotective doses of almagate. Pretreatment with sucralfate, another aluminium containing compound, at doses of 250 μmiol kg−1 protected the mucosa, although lower doses did not. The present study has shown that almagate prevents ethanol-induced gastric mucosal damage. This protective effect seems independent of any antacid activity, related to its content in magnesium, and mediated by an increase in gastroprotective prostaglandins in the mucosa of the stomach.

One of the major goals of engine designers is the reduction of fuel consumption and pollutant emissions while keeping or even improving engine performance. In recent years, different technical issues have been investigated and incorporated into internal combustion engines in order to fulfill these requirements. Most are related to the combustion process since it is responsible for both fuel consumption and pollutant emissions. Additionally, the most critical operating points for an engine are both the starting and the warming up periods (the time the engine takes to reach its nominal temperature, generally between 80°C and 90°C), since at these points fuel consumption and pollutant emissions are larger than at any other points. Thus, reducing the warm-up period can be crucial to fulfill new demands and regulations. This period depends strongly on the engine cooling system and the different strategies used to control and regulate coolant flow and temperature. In the present work, the influences of different engine cooling system configurations on the warm-up period of a Diesel engine are studied. The first part of the work focuses on the modeling of a baseline engine cooling system and the tests performed to adjust and validate the model. Once the model was validated, different modifications of the engine coolant system were simulated. From the modelled results, the most favourable condition was selected in order to check on the test bench the reduction achieved in engine warm-up time and to quantify the benefits obtained in terms of engine fuel consumption and pollutant emissions under the New European Driving Cycle (NEDC). The results show that one of the selected configurations reduced the warm-up period by approximately 159 s when compared with the baseline configuration. As a consequence, important reductions in fuel consumption and pollutant emissions (HC and CO) were obtained.

Access to reliable and affordable energy is vital for sustainable development. In the off-grid areas of developing countries, decentralized energy solutions have received increasing attention due to their contributions to reducing poverty. However, most of the rural population in many developing countries still has little or no access to modern energy technologies. This paper assesses the factors that determine the successes and failures of decentralized energy solutions based on local harmonized case studies from heterogeneous contexts from Asia, sub-Saharan Africa, and South America. The case studies were analyzed through the coupled lenses of energy transition and the Water–Energy–Food Security (WEF) Nexus. The findings indicate that access to modern decentralized energy solutions has not resulted in complete energy transitions due to various tradeoffs with the other domains of the WEF Nexus. On the other hand, the case studies point at the potential for improvements in food security, incomes, health, the empowerment of women, and resource conservation when synergies between decentralized energy solutions and other components of the WEF Nexus are present.

Alkali activation is a highly active and rapidly developing field of activity in the global research and development community. Commercial-scale deployment of alkali-activated cements and concretes is now proceeding rapidly in multiple nations. This paper reviews the key developments in alkali-activated materials since 2011, with a particular focus on advances in characterisation techniques and structural understanding, binder precursors and activation approaches, durability testing and design, processing, and sustainability. The scientific and engineering developments described in this paper have underpinned the on-going scale-up activities. We also identify important needs for future research and development to support the optimal and appropriate utilisation of alkali activated materials as a component of a sustainable future construction materials industry. The contributions of JLP were supported by the European Research Council 7th Framework Programme, through the Starting Grant “GeopolyConc” (StG-335928), those of C. Shi were supported by the National Natural Science Foundation of China under contract Nos. U1305243 and 51378196.

Spain has a high level of energy consumption and CO2 emissions in detached houses, being the lack of an adequate insulation level and efficient energy systems the main causes. The Spanish Government has been performing modifications on its Building Technical Code (BTC) to address this issue, following European Directives. An assessment of the development of the Spanish BTC from its first 2006 version has been conducted in this work. A standard Spanish detached house was placed in the different Spanish climatic zones, designed with the minimum requirements of the 2006 and 2013 BTCs, and was then analyzed using the software Cerma. The results show that energy demand is reduced and the energy rating is improved with the stricter requirements introduced in the 2013 BTC. Although energy demand and CO2 emissions vary significantly among the 13 different climatic zones studied, the BTC modifications allow to reach a minimum energy rating independently of the climatic zone where the house is located. Opaque enclosures and internal loads were found to be the main contributors to building-related emissions. Additionally, possible actions to improve energy rating in detached houses are evaluated, finding that a moderate insulation thickness increase and the installation of heat pumps allow to reach the highest energy rating, being the improvement more apparent in northern and central regions. The results of this work may be extrapolated to other countries with similar climatic conditions to the studied zones, providing guidelines to fulfill energy saving regulations, evaluate emission sources and improve building energy efficiency.

Background and Aims: Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as a mediator for ALD progression and hypothesize that targeting MCJ may help in recovering mitochondrial fitness without collateral oxidative damage. Approach and Results: C57BL/6 mice [wild-type (Wt)] Mcj knockout and Mcj liver-specific silencing (MCJ-LSS) underwent the NIAAA dietary protocol (Lieber-DeCarli diet containing 5% (vol/vol) ethanol for 10 days, plus a single binge ethanol feeding at day 11). To evaluate the impact of a restored mitochondrial activity in ALD, the liver, gut, and pancreas were characterized, focusing on lipid metabolism, glucose homeostasis, intestinal permeability, and microbiota composition. MCJ, a protein acting as an endogenous negative regulator of mitochondrial respiration, is downregulated in the early stages of ALD and increases with the severity of the disease. Whole-body deficiency of MCJ is detrimental during ALD because it exacerbates the systemic effects of alcohol abuse through altered intestinal permeability, increased endotoxemia, and dysregulation of pancreatic function, which overall worsens liver injury. On the other hand, liver-specific Mcj silencing prevents main ALD hallmarks, that is, mitochondrial dysfunction, steatosis, inflammation, and oxidative stress, as it restores the NAD+/NADH ratio and SIRT1 function, hence preventing de novo lipogenesis and improving lipid oxidation. Conclusions: Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.

The united nations educational, scientific and cultural organization (UNESCO) considers the historic urban landscapes as the world heritages. Managing historic city centers and maintaining historic cores are the emerging challenges for sustainable urban planning. Today, the historic cores form an important part of the economic, social, environmental, and physical assets and capacities of contemporary cities, and play a strategic role in their development. One of the most important approaches to the development of central textures, especially in historical and cultural cities, is the sustainable urban regeneration approach, which encompasses all aspects of sustainability, such as the economic, social, cultural and environmental aspects. To maintain sustainability and regeneration of historic cores of cities, it is necessary to provide insight into the underlying characteristics of the local urbanization. Furthermore, the fundamental assets are to be investigated as indicators of sustainable regeneration and drivers of urban development. In the meantime, a variety of research and experience has taken place around the world, all of which has provided different criteria and indicators for the development of strategies for the historic cores of cities. The present study, through a meta-analytic and survey method, analyzing the experience and research reported in 139 theoretical and empirical papers in the last twenty years, seeks to provide a comprehensive conceptual model taking into account the criteria and indices of sustainable regeneration in historic cores of cities. The quality of the survey has been ensured using the preferred reporting items for systematic reviews and meta-analysis (PRISMA).