The united nations educational, scientific and cultural organization (UNESCO) considers the historic urban landscapes as the world heritages. Managing historic city centers and maintaining historic cores are the emerging challenges for sustainable urban planning. Today, the historic cores form an important part of the economic, social, environmental, and physical assets and capacities of contemporary cities, and play a strategic role in their development. One of the most important approaches to the development of central textures, especially in historical and cultural cities, is the sustainable urban regeneration approach, which encompasses all aspects of sustainability, such as the economic, social, cultural and environmental aspects. To maintain sustainability and regeneration of historic cores of cities, it is necessary to provide insight into the underlying characteristics of the local urbanization. Furthermore, the fundamental assets are to be investigated as indicators of sustainable regeneration and drivers of urban development. In the meantime, a variety of research and experience has taken place around the world, all of which has provided different criteria and indicators for the development of strategies for the historic cores of cities. The present study, through a meta-analytic and survey method, analyzing the experience and research reported in 139 theoretical and empirical papers in the last twenty years, seeks to provide a comprehensive conceptual model taking into account the criteria and indices of sustainable regeneration in historic cores of cities. The quality of the survey has been ensured using the preferred reporting items for systematic reviews and meta-analysis (PRISMA).