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CK2 is a highly conserved protein kinase involved in different cellular processes, which shows a higher activity in actively proliferating mammalian cells and in various types of cancer and cancer cell lines. We recently demonstrated that CK2 activity is strongly influenced by growth rate in yeast cells as well. Here, we extend our previous findings and show that, in cells grown in either glucose or ethanol-supplemented media, CK2 presents no alteration in K(m) for both the ATP and the peptide substrate RRRADDSDDDDD, while a significant increase in V (max) is observed. In chemostat-grown cells, no difference of CK2 activity was observed in cells grown at the same dilution rate in media supplemented with either ethanol or glucose, excluding the contribution of carbon metabolism on CK2 activity. By using the eIF2β-derived peptide, which can be phosphorylated by the holoenzyme but not by the free catalytic subunits, we show that the holoenzyme activity requires the concurrent presence of both β and β' encoding genes. Finally, conditions of nitrogen deprivation leading to a G0-like arrest result in a decrease of total CK2 activity, but have no effect on the activity of the holoenzyme. These findings newly indicate a regulatory role of β and β' subunits of CK2 in the nutrient response.

Energy management is an enabling technique to guarantee the reliability and economy of hybrid electric systems. This paper proposes a novel machine learning-based energy management strategy for a hybrid electric bus (HEB), with an emphasized consciousness of both thermal safety and degradation of the onboard lithium-ion battery (LIB) system. Firstly, the deep deterministic policy gradient (DDPG) algorithm is combined with an expert-assistance system, for the first time, to enhance the “cold start” performance and optimize the power allocation of HEB. Secondly, in the framework of the proposed algorithm, the penalties to over-temperature and LIB degradation are embedded to improve the management quality in terms of the thermal safety enforcement and overall driving cost reduction. The proposed strategy is tested under different road missions to validate its superiority over state-of-the-art techniques in terms of training efficiency and optimization performance.

AbstractThe co‐occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co‐occur. There is also an indication of a gender‐dependent effect; males are more likely to use alcohol to cope with chronic pain problems than females. Recently, a new conceptualization has emerged, proposing that the negative affective component of pain drives and maintains alcohol‐related behaviors. We studied in a longitudinal fashion alterations in alcohol drinking patterns and pain thresholds in a mouse model of chronic neuropathic pain in a sex‐dependent manner. Following partial denervation (spared nerve injury [SNI]), stimulus‐evoked pain responses were measured before chronic alcohol consumption, during drinking, during a deprivation phase, and following an episode of excessive drinking. During the course of alcohol drinking, we observed pronounced sex differences in pain thresholds. Male mice showed a strong increase in pain thresholds, suggesting an analgesic effect induced by alcohol over time, an effect that was not observed in female mice. SNI mice did not differ from sham‐operated controls in baseline alcohol consumption. However, following a deprivation phase and the reintroduction of ethanol, male SNI mice but not female mice showed more pronounced excessive drinking than controls. Finally, we observed decreased central ethanol sensitivity in male SNI mice but not in females. Together with our finding, that ethanol is able to decrease a pain‐induced negative affective memory we come to following conclusion. We propose that a lower sensitivity to the intoxicating effects of alcohol together with the ability of alcohol to reduce the negative affective component of pain may explain the higher co‐occurrence of AUD in male chronic pain patients.

The Soutpansberg Transect investigates the abundance and diversity of ants and spiders along an altitudinal gradient in the Western Soutpansberg Mountains, South Africa. It has a north-south orientation over the mountain and is a long term project initiated in 2009. Data collection is carried out in intervals that suit the data logger capacity. To study the diversity patterns in ants and other invertebrate groups across the spatial transect over a long-term period and the climate the invertebrates.

We studied the performance of the AZTI Marine Biotic Index AMBI manipulating input data collected from lagoonal ecosystems. Our data set consisted of macrofaunal abundance and biomass counts gathered at a variety of sites at which the disturbance status was known. Input data were also manipulated using a set of transformations of increasing severity. Biotic indices were calculated using raw and transformed abundance, biomass and production. Among the three categories of AMBI-based indices, medium transformation of data gave the highest correlation with pressures. However, increasing the severity of transformation generally resulted in a decrease of the correlation with environmental factors. The relative importance of ecological groups changed when using abundance or biomass, sometimes leading to an improved ecological status classification. Being biomass and production more ecologically relevant than abundance, using them to derive AMBI-based new indices seems intriguing, at least in lagoonal waters, where the community is naturally disturbed and dominated by opportunists.

Abstract Membrane separation of absorption solutions has potential application in refrigeration technology. Operating osmotic pressure is a basic parameter governing the design and evaluation of a membrane separation absorption system. This study presents a thermodynamic approach to calculating the osmotic pressure of an absorption solution using its density and vapour pressure. A correlation between osmotic pressure, density and vapour pressure has been deduced and a calculation example is given. Furthermore, combination of this correlation with the Clausius–Clapeyron equation has produced a simple and interesting result. For a membrane separation absorption cycle, the operating osmotic pressure required is related to the specific latent heat of refrigerant, operating temperatures and density of absorption solution.

Abstract In this study, soil temperatures at different depths in Turkey's different regions were investigated theoretically. Soil temperature data are critical for different research interests such as ecology, biology, technique processes, forestry, agriculture, energy, food sector, ground heat exchanger applications, thermal energy storage applications, and so forth. This investigation gives information related to the prediction of soil temperature's dependence with depth and time especially for shallow geothermal applications. Soil temperature values depend on a great deal of varied parameters such as thermal conductivity, short term climatic conditions and moisture content. The main issue is that despite these temperatures are extremely important values, they can not be obtained in a short time. Due to this reason, we study a mathematical model related to the prediction of soil temperature. Within this context, 81 cities and their approximately 300.000 data, both, monthly air and soil temperatures between 1960 and 2015 were studied and finally seven regions in Turkey were investigated and final average soil temperature values were achieved. Measured data taken from the Izmir State Meteorological Station, and predicted soil temperatures at depths of 5 cm, 10 cm, 20 cm, 50 cm, and 100 cm were analyzed for each region in Turkey according to data obtained fifty years ago. Finally, at depths of 5 cm, 10 cm, 20 cm, 50 cm and 100 cm, the maximum average percentage errors in Turkey were 16%, 14.8%, 13.5%, 14.4%, 13.9% respectively. In conclusion, we evaluate the relationship between ambient air temperatures and soil temperatures in terms of depths from 5 to 3000 cm.

Highly efficient nanocatalysts which can selectively decompose hydrous hydrazine for hydrogen production are introduced.