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In order to improve the applicability to products having a large number of holes, the greedy algorithm is used in the process of searching for the solution. The constitution of the system was confirmed to be valid from a comparison between the machining time obtained by a proposed system and operator design. Then, the cutting force in milling and drilling processes performed on a workpiece having a large number of holes and steps is calculated through application of cutting models proposed by Usui et al., and the machining power and electric energy are estimated on the basis of the calculated cutting force. To enable process planning in which two objective functions such as machining time and electric energy are taken into consideration, it is proposed that convert those quantities to cost.

がん抑制遺伝子産物p53は「the guardian of the genome: ゲノムの守護神」として生体を癌から防ぐという機能以外にも,多種多様な生体ストレスに対する応答と細胞の恒常性維持に働くことから「cellular gatekeeper: 細胞の番人」とも称されている。癌細胞でのWarburg効果に関連した解糖系の制御機能だけでなく,肥満や糖尿病,動脈硬化や心不全などの病態におけるp53の役割も報告されている。癌と生活習慣病を結び付ける分子病態の根底に存在するメカニズムが注目を集める中で,細胞レベルでのエネルギー・代謝調節機構が明らかにされつつある。

Linear thermal expansion and electrical conductivity of titanium substituted LaCrO_3 have been studied as ceramic interconnect materials in high-temperature solid oxide fuel cells. The transition temperature from orthorhombic to rhombohedral symmetry has a tendency to increase with decreasing Ti content in the perovskites. At Ti content ≧0.2, the phase transition was not observed in the temperature range from room temperature to 1273 K. Average linear thermal expansion coefficient of the Ti substituted perovskites increased with increasing Ti content and approaches that of 8 mol%Y_2O_3 stabilized ZrO_2 electrolyte. Electrical conductivity of the lanthanum chromites decreased with increasing Ti content.

To predict the water temperature in lower reaches of urban rivers, field measurements and model development were performed for simultaneous transport of water and heat in a stream. Detailed information on river flow and heat transport under tidal motion was obtained through an intensive measurement in the lower reach of the Ara River. Based on the knowledge of time variations and cross-sectional profiles of the flow and the stream temperature, a one-dimensional dynamic model is developed to predict flow and water temperature in tidally affected urban streams. The model takes into account of tidal motion, longitudinal dispersion, water exchange with tributaries, wastewater effluent and the heat exchange between the atmosphere and the stream water. Using the calibrated model, effects of heated water discharge on the stream temperatures due to the district heating and cooling system were estimated for a possible scenario in which the river thermal energy is used through the water heat pump technology.

筆者らは千葉大学地球科学教育研究会を組織し,児童生徒にとって好ましい地球科学的体験を体系化することを試みている。この組織は,小学校高学年から中学校の児童生徒を対象に,講演と野外宿泊体験を組み合わせた科学体験活動「地球探検隊」を毎年開催している。我々は,科学体験活動の中で,人類の獲得した知識や技術を歴史的に考察することも行った。今回は福島県いわき地方で,宇宙と恐竜と石炭に焦点を当てた科学体験活動を展開した。その結果を報告する。 ; We organize Association for Chiba University Earth Science Education, and try to systematize an experience like desirable earth science for the children. This organization holds the practice that a field outside staying experience that was combined with the lecture for the children of the junior high school from the elementary school upper grades, "Earth Expeditionary Party" every year. We did the matter that the knowledge which mankind got, and technology were examined historically, in science experience activities. This time, we developed science experience activities that a focus was exposed to the universe, the coal, and the dinosaur in Fukushima Prefecture Iwaki area. That result is reported.

ベンゼン, エタノール, 水系に対する共沸蒸留計算を緩和法を用いて行い, 種々の操作条件に対して分離数および熱力学的効率の両面から最適操作条件を検討した。気液モル流量比に関しては第1塔は1.3以下, 第2塔は1.2以下が望ましい。また塔内圧力が上昇すると, エタノールと水の分離が悪くなり, 分離数および熱力学的効率が低下する。さらにベンゼン相と水相の分離を良くするために, デカンターに水を供給した場合, エタノールと水の分離は良くなるが, リボイラー部での必要熱量が増加すること等の新しい知見を得た。 The relaxation method was used for azeotropic distillation calculations. For the Benzene-Ethanol-Water system, various operating conditions were examined by use of thermodynamic efficiency and separation number. For vapor-liquid calculations NRTL Eq. was used, and Eq. (3) was used for separation number calculations. Eqs. (4), (5), (6) were used for thermodynamic efficiency calculations. A schematic drawing of azeotropic distillation column is shown in Fig. 1. It was found from Figs. 3, 4, 5 that the ratio of liquid to vapor flow rate for the first column should be less than 1.3. From Figs. 6, 7, 8, it was also found that the ratio of liquid to vapor flow rate for the second column should be less than 1.2. Fig. 9 shows that both the thermodynamic efficiency and separation number were maximized when the temperature of the feed was in the boiling condition. The maximum thermodynamic efficiency was about 0.07. Figs. 10, 11, indicated that as the pressure of the column decreased, the separation of ethanol and water improved. Fig. 11, showed that as the pressure increased, the thermodynamic efficiency decreased. Fig. 12 shows the relation between mole fraction of bottom liquid and water feed rate to the decanter. It indicated that as the water feed rate to the decanter increased, the separation of bottom liquid in the second column improved. But from Fig. 13, it was observed that the greater the water feed rate to the decanter was the greater the reboiler duty.

Low-power laser irradiation on oral tissue is reported to have healing effects caused by accelerating cell growth. However, the effects of high-power laser irradiation on cell growth are unknown. To investigate the effects of high-power laser irradiation on oral tissue, we examined the cell growth of fibroblasts (Balb/3T3(clone)A31), osteoblasts (MC3T3-E1) and epithelial cells (normal human gingival keratinocytes) after laser irradiation in vitro using MTT assay. Cells were cultured during 1 day following laser irradiation once for 30, 60, 90, 120 and 180 seconds with a diode laser (830±10nm, GaAlAs diode, continuous wave, 400mW or 800mW). Non-irradiation cells were used as the control group. As a result, fibroblasts and epithelial cells showed good cell growth under the irradiation of 3.7mW/cm^2 for 90seconds. The irradiation of 3.7mW/cm^2 for 90seconds and of 6.7mW/cm^2 for 60seconds accelerated the cell growth of osteoblasts. These results suggest that laser irradiation of 3.7mW/cm^2 for 90seconds accelerates cell growth. In addition, power density (mW/cm^2) and irradiation time (seconds) are more closely related to cell growth in vitro than to energy density (J/cm^2).

The biological effectiveness of charged-particle beams depends not only on dose but also on radiation quality. The radiation quality of charged-particle beams has been most commonly represented by the linear energy transfer (LET) in radiation biology studies. We investigated a new therapeutic technique of charged-particle therapy in which two or more ion species are delivered in one treatment session for optimizing the dose and LET distributions in a patient. We refer the therapeutic technique as an Intensity Modulated composite PArtiCle Therapy (IMPACT). Helium, carbon, oxygen and neon ions are considered as ion species for the IMPACT. To demonstrate the effectiveness of the IMPACT for simultaneous optimization of dose and LET distributions, an IMPACT plan was made for a prostate case. In accordance with the prescriptions, LETs in prostate, planning target volume (PTV), and rectum could be adjusted at 80 keV/μm, at 50 keV/μm, and below 30 keV/μm, respectively, while keeping the dose to the PTV at 2 Gy uniformly. The IMPACT enables the optimization of the dose and the LET distributions in a patient, which will maximize the potential of charged-particle therapy by expanding the therapeutic window.

The environmental tolerance should not exceed the global self-purification capacity. The industrial revolution that began with the invention of the steam engine is the large scale of energy consumption industry, and creates out electricity and car civilized society. When it tries to arrange the energy resource with firewood, coal, petroleum, natural gas, methane hydrate, the hydrogen of the energy efficiency is better than that of the carbon in the direction of the decarbonization element, decarbonization element will show the new industry society.

修士(工学) ; 法政大学 (Hosei University)