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Lysophosphatidic acid species (LPA) are lipid bioactive signaling molecules that have been recently implicated in the modulation of emotional and motivational behaviors. The present study investigates the consequences of either genetic deletion or pharmacological blockade of lysophosphatidic acid receptor-1 (LPA1) in alcohol consumption.The experiments were performed in alcohol-drinking animals by using LPA1-null mice and administering the LPA1 receptor antagonist Ki16425 in both mice and rats.In the two-bottle free choice paradigm, the LPA1-null mice preferred the alcohol more than their wild-type counterparts. Whereas the male LPA1-null mice displayed this higher preference at all doses tested, the female LPA1-null mice only consumed more alcohol at 6% concentration. The male LPA1-null mice were then further characterized, showing a notably increased ethanol drinking after a deprivation period and a reduced sleep time after acute ethanol administration. In addition, LPA1-null mice were more anxious than the wild-type mice in the elevated plus maze test. For the pharmacological experiments, the acute administration of the antagonist Ki16425 consistently increased ethanol consumption in both wild-type mice and rats; while it did not modulate alcohol drinking in the LPA1-null mice and lacked intrinsic rewarding properties and locomotor effects in a conditioned place preference paradigm. In addition, LPA1-null mice exhibited a marked reduction on the expression of glutamate-transmission-related genes in the prefrontal cortex similar to those described in alcohol-exposed rodents.Results suggest a relevant role for the LPA/LPA1 signaling system in alcoholism. In addition, the LPA1-null mice emerge as a new model for genetic vulnerability to excessive alcohol drinking. The pharmacological manipulation of LPA1 receptor arises as a new target for the study and treatment of alcoholism.

Intention of this work is to investigate the opportunity and feasibility of energy efficient networking in Home and Building automation protocols. Wired HBAS have traditionally devoted a relatively little attention to this point, especially if compared to wireless networks. This paper will try to address the issue by evaluating the introduction of power state switching in a real scenario and proposing the concept of functional and spatial adjacency among packets.

Abstract This work assesses the impacts of aggressive driving behavior on pollutants emissions and energy consumption at a city level. Furthermore, it performs an economic analysis considering the potential avoided emissions and fuel savings and discusses potential policy measures to address this topic. The results showed that aggressive driving significantly impacts energy consumption and emissions, with energy consumption increasing by more than ∼200% and emissions by 330% for aggressive driving compared to non-aggressive driving (in MJ/km and in g/km, respectively). This increment was found to be even higher for diesel vehicles than for gasoline vehicles. On the contrary, gasoline vehicles showed higher percentages of increase for most emissions (CO, NOx and NO). Results also revealed that aggressive driving impacts are higher for local streets when examining the city level. Moreover, the economic analysis showed that significant cost reductions may be achieved by avoiding aggressive driving, reaching up to 52.5 k€ on a daily basis. In conclusion, this study is of particular relevance to policy makers and urban planners, enabling to obtain a comprehensive overview of the impacts of aggressive driving behaviors at a city level and providing new insights to perform further developments and to assess the feasibility of the implementation of policy measures.

The aim of this report is to demonstrate and evaluate the potential of tall wheatgrass (Elytrigia elongata) to avoid GHG emissions and obtain lower economic costs in marginal areas of Spain. Our research built scenarios based on experimental plots (2 and 3 years growth) in 3 locations of Spain with completely different climate conditions (provinces of Girona, Soria and Palencia). In our experiences, we achieved an adequate establishment and biomass production, and assumed a rank of biomass yields until the end of the life cycle that is usually accepted to be about 15 years in many other studies in United States, Argentina and Eastern Europe where tall wheatgrass is extensively cultivated in marginal areas for sheep livestock production. Using our experimental plots and statistical information for economic inputs costs, we built 5 different scenarios per region considering a large range of biomass yields of tall wheatgrass. The analysis included a comparison with annual grasses economic costs calculated for a wide range of biomass yields of a previous study. We estimated GHG emissions savings for tall wheatgrasses and used our previous study (which had GHG emissions savings as well). Savings were calculated replacing natural gas electricity with electricity from biomass combustion in real power plants in Spain. In a wide range of yields, the results suggest that marginal areas might present a better performance with tall wheatgrass compared to annual winter grasses (cereals whole plant cuttings), thus producing biomass yields with higher GHG savings and lower economic costs at the farm level. Proceedings of the 20th European Biomass Conference and Exhibition, 18-22 June 2012, Milan, Italy, pp. 217-229

Capítulos en libros This paper introduces a methodology to assist generation companies to deal with planning decisions in a competitive framework. It is based on a two-stage representation of market equilibrium. A first level computes an approximate continuous Cournot equilibrium for the entire model horizon. The second one discretises this solution separately for each year. Some aspects of its practical implantation are discussed. info:eu-repo/semantics/publishedVersion

Artículos en revistas Multi-terminal High Voltage Direct Current (HVDC) using Voltage Source Converters (VSC-HVDC) is a promising technology which provides flexible control of active and reactive power and facilitates remote renewable energy integration, above all using long cables. This paper analyses an active power control strategy for multi-terminal VSC-HVDC systems tailored to enhance transient stability of hybrid AC/DC grids. The proposed strategy controls each VSC using frequency measurements of all terminals. Its performance is compared to a strategy in which each VSC is controlled using only local frequency measurements of the AC side, proving that the proposed strategy shows better performance, even taking into account reasonable communication delays. The paper also shows that the proposed strategy generally gives similar results to those obtained when each VSC is controlled using the speed of the centre of inertia (COI). The speed of the COI is a more comprehensive and richer figure than the one proposed in this paper but it is also much more complex to obtain. Simulation results with PSS/E of a test system have been used to illustrate the comparisons and the main contributions of the proposal. info:eu-repo/semantics/publishedVersion

Thermal performance of SS-PCM composites, simulating building envelope conditions, is difficult to asset with traditional laboratory equipment. However, in this work, the evaluation of three SS-PCM based on eutectic fatty acid mixtures of capric-myristic (CA/MA), lauric-myristic (LA/MA) and palmitic-stearic (PA/SA) was accomplished by a testing setup that allows to test samples in steady-state and dynamic conditions. Moreover, a SS-PCM-based acrylic plaster was evaluated as a fiber cement siding finish. The obtained values were used to calculate the thermal transmittance (U-value), heat storage capacity, and thermal inertia parameters under a simulated diurnal cycle. Results showed that the use of phase change materials in powder form increase thermal lag between 148% and 180% and present a decrement factor <0.2. Furthermore, building envelopes as fiber cement siding with a SS-PCM-based acrylic plaster coating decreased 20.8% the indoor temperature, increase 67.26% the thermal lag and decrease 9% of the decrement factor. The authors are pleased to acknowledge the financial assistance of the “Ministerio de Ciencia, Tecnología e Innovación-MINCIENCIAS” through the PhD grant 758-2016-Contract 036–2016, Universidad de Antioquia and Sumicol S.A.S. The work is partially funded by the Ministerio de Ciencia, Innovación y Universidades de España (RTI2018-093849-B-C31—MCIU/AEI/FEDER, UE) and by the Ministerio de Ciencia, Innovación y Universidades—Agencia Estatal de Investigación (AEI) (RED2018-102431-T). This work is partially supported by ICREA under the ICREA Academia programme. Dr. Cabeza would like to thank the Catalan Government for the quality accreditation given to her research group GREiA (2017 SGR 1537). GREiA is a certified agent TECNIO in the category of technology developers from the Government of Catalonia.

Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.