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Alcohol use, binge drinking, and alcohol use disorders have been increasing among older adults in the US population, including adults over 50 as well as adults over 65. Increases in consumption are sharper among women, and among those who use additional substances such as cannabis, and those who are relatively healthy in older adulthood (i.e. those without multimorbidites). This commentary describes these trends as well as provides hypotheses, and the data underlying them, for both supply-side (alcohol marketing and messaging) and demand-side (healthier aging, increased financial stress) potential drivers of these increases. The need for additional resources and focus on older adult drinking is increasingly urgent, as alcohol-attributable deaths escalate among older adults in the United States.

The global community has set intensive targets in Sustainable Development Goals (SDGs) to better people’s lives after closing the Millennium Development Goals (MDGs). It corresponds to the 2030 aspirations of the United Nations to enhance and promote the sustainable development of human society. The current paper explores the impact of fiscal hedging and R&D in energy Using a green-energy system in SDGs. To do this, we used TOPSIS and QARDL methodologies on a 21-year dataset of South and Southeast Asian economies from 2000 to 2020. The study results show that fiscal hedging contributes favourably to the environmental degradation of the underlying economy. Research and development (R&D) in renewables has contributed negatively to ecological degradation and SDGs in the economies of South & Southeast Asia. This study suggests policy guidelines for advanced and developing economies based on fiscal stability and technical innovation through R&D to meet SDG.

Abstract China's carbon emissions have been ranking first in the world. This study filled in the gaps in research, decomposed carbon intensity from the perspective of time, space and industry. A decoupling effort model based on factor decomposition models was constructed to analyze the driving factors of carbon emissions and economic decoupling, which builded a foundation for achieving sustainable economic development. Using the Logarithmic Mean Divisia Index method (LMDI), the paper measured the carbon emission intensity of 29 provinces and cities in China from 1998 to 2019, and decomposed the decoupling effect between GDP and carbon emission on the basis of factor decomposition by tapio. The results showed that: (1) Carbon intensity declined first, then rise lightly, and finally declined steadily. For the primary industry and the tertiary industry, the carbon intensity declined steadily, while the carbon intensity increased accordingly to the overall carbon intensity. In terms of spatial evolution, the regional differences between different provinces decreased correspondingly. (2) The cumulative contribution rates of these three effects, i.e., technological progress, industrial structure and regional scale were 106.3299%, −15.1486% and 8.8188%, respectively. There were obvious differences of these cumulative contribution rates of carbon intensity among different provinces. (3) From the perspective of industrial, technological progress effect is the largest contribution for carbon intensity in the secondary industry. The Industrial structure effect mainly affects the primary and tertiary industries; and no significant difference in regional scale effect. (4) The decoupling effect gradually improved, and technological progress has played an absolute leading role in promoting the decoupling effect. Based on the research results, the key policy recommendation are put forward as follows: (1) Further improve the technological level and support clean technology enterprises. (2) Promote industrial upgrading in backward industrial provinces (3) Promote regional assistance and the introduction of high-quality foreign investment.

Abstract When a lithium ion polymer battery (LiPB) is being cycled, one major cause for degradations is the irreversible side reactions between ions and solvent of electrolyte taking place at the surface of anode particles. SEM analysis of cycled battery cells has revealed that the deposits from the side reactions are dispersed not only on particles, but also between the composite anode and the separator. Thus, the solid electrolyte interface (SEI) becomes thicker and extra deposit layers are formed between composite anode and separator. Also, XPS analysis showed that the deposits are composed of Li 2 CO 3 , which is ionic conductive and electronic nonconductive. Based on the mechanisms and findings, we identified four degradation parameters, including volume fraction of accessible active anode, SEI resistance, resistance of deposit layer and diffusion coefficient of electrolyte, to describe capacity and power fade caused by the side reactions. These degradation parameters have been incorporated into an electrochemical thermal model that has been previously developed. The terminal voltage and capacity of the integrated model are compared with experimental data obtained for up to 300 cycles. Finally, the resistance of the deposit layer calculated by the model is validated against the thickness of the deposit layer measured by SEM.

With rapid progress in the corporate social responsibility (CSR) theories and the up-gradation of the global market information disclosure system, enterprises have increased their attention toward relevant stakeholders and social responsibility. CSR exerts a substantial impact on the sustainable development of enterprises and markets in the economic and social fields. On the one hand, the increasingly perfect supporting facilities promote the financial growth of the entire society. While on the other hand, the profit-seeking trend of capital is also on the rise. The incongruity between the rapid progress of enterprises and the lack of social responsibility limits the benign development of the market. This study discusses the antecedents of CSR from the variable combination perspective using the fuzzy-set qualitative comparative analysis. It also investigates which combination of characteristics has better CSR performance. After the configuration analysis, it is identified that four paths lead to high CSR performance. These include the market-developed type, political link type, financial performance type, and state-owned enterprise subsidy type, and the level of each type is explained in-depth. Finally, this study provides management inspiration for the government and enterprises to formulate a sound social responsibility strategy and improve CSR performance by optimizing the matching of CSR activities and business objectives.

Sphingosine is known to have potent biological activity, including pronounced anti-microbial action in vitro against Candida albicans and some bacteria. Several sphingosine bases are present in stratum corneum at concentrations several orders of magnitude above those in other tissues. Sphingosine forms an undissociated salt with organic sulfates, however, so that the free sphingosine in the epidermis may be inactivated by the cholesterol sulfate known to be present. To investigate this hypothesis, C. albicans was grown in cultures with graded concentrations of sphingosine added in ethanol. In 1% ethanol, 0.1-100 microgram/ml sphingosine completely prevented growth of the organism for 12 h. All cultures eventually entered log-phase growth and reached limiting density at a rate inversely proportional to sphingosine concentration. When sphingosine was added, together with an equimolar amount of cholesterol sulfate, there was no delay in the onset of growth of the yeast and the rate of growth and final density were similar to control cultures. These results demonstrate that natural ratios of cholesterol sulfate neutralize the anti-microbial activity of sphingosine in vitro. In the epidermis, endogenous cholesterol sulfate is hydrolyzed by sterol sulfatase at the skin surface, where the released sphingosine may resist microbial colonization of the stratum corneum. This mechanism for liberating anti-microbial sphingosine base only at the skin surface may protect the viable epidermis against known cytotoxic effects of free sphingosine.

Abstract The ecological footprint is a measure of the resources necessary to produce the goods that an individual or population consumes. It is also used as a measure of sustainability, though evidence suggests that it falls short. The assumptions behind footprint calculations have been extensively criticized; I present here further evidence that it fails to satisfy simple economic principles because the basic assumptions are contradicted by both theory and historical data. Specifically, I argue that the footprint arbitrarily assumes both zero greenhouse gas emissions, which may not be ex ante optimal, and national boundaries, which makes extrapolating from the average ecological footprint problematic. The footprint also cannot take into account intensive production, and so comparisons to biocapacity are erroneous. Using only the assumptions of the footprint then, one could argue that the Earth can sustain greatly increased production, though there are important limitations that the footprint cannot address, such as land degradation. Finally, the lack of correlation between land degradation and the ecological footprint obscures the effects of a larger sustainability problem. Better measures of sustainability would address these issues directly.

The abilities of antacid (Mylanta II), sucralfate, cimetidine, and ranitidine to protect the gastric mucosa against ethanol-induced necrosis were compared in a standardized, experimental rat model. Fasted rats received pretreatment with either saline, Mylanta II, 500 mg/kg of sucralfate, 50 mg/kg of cimetidine, or 50 mg/kg of ranitidine. This was followed one hour later by intragastric administration of 2 ml of 100 percent ethanol. Gastric mucosal injury was assessed four hours after administration of ethanol by quantitation of gross mucosal necrosis, assessment of mucosal histology, and determination of intragastric blood and protein concentrations. Pretreatment with Mylanta II or sucralfate significantly reduced ethanol-induced gastric mucosal necrosis. The protective effect of sucralfate was six to 10 times greater than that of Mylanta II. H2-receptor antagonists increased ethanol-induced gastric mucosal necrosis.

Basal levels of serum thyroid‐stimulating hormone (TSH). T3, T4, free T3 and free T4 were measured in 40 chronic alcoholic men and in 31 normal volunteers. Their serum TSH responses to provocative thyrotropin‐releasing hormone (TRH) stimulation were then examined serially: in chronic alcoholics, every 5 days for a total of 3 studies; in 25 of the normal volunteers, before and 72 hr after daily ingestion of ethanol (2 cc/kg/day). Basal serum TSH levels were increased in the alcoholic men (3.5 ± 0.2 μU/ml) (mean ± SEM) compared to those of the normal controls (1.7 ± 0.1) (p < 0.01). Both basal serum T3 and T4 levels (T3, 0.89 ± 0.10 ng/ml; T4, 7.0 ± 0.4 μg/dl) were reduced in the alcoholic men when compared to those of the normal controls (T3,1.20 ± 0.03 ng/ml; T4, 8.6 ± 0.3 μg/dl) (p < 0.01 and p < 0.05, respectively). Basal serum free T3 levels were reduced in the alcoholic men (169 ± 22 pg/dl) compared to the normal controls (380 ± 18) (p < 0.01). In contrast, basal serum free T4 levels were increased in the alcoholics (4.0 ± 0.2 ng/dl) compared to those of the normal controls (2.9 ± 0.1) (p < 0.01). In response to TRH, the serum TSH levels of the alcoholic men achieved a peak of 13.5 ± 0.9 μU/ml compared to 14.9 ± 0.9 for the normal controls (no significant difference). Despite better nutrition and alcohol abstinence associated with hospitalization for 10 days, no improvement in either the basal levels of TSH, T3, and T4 or the TSH responses to provocative TRH was observed in the alcoholic men studied. In normal volunteers, ethanol had no effect on the basal or TRH‐stimulated levels of serum TSH and thyroid hormones.